| Determination of fractional flow reserve (FFR) based on scaling laws: a simulation study. | |
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MedLine Citation:
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PMID: 18596370 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fractional flow reserve (FFR) provides an objective physiological evaluation of stenosis severity. A technique that can measure FFR using only angiographic images would be a valuable tool in the cardiac catheterization laboratory. To perform this, the diseased blood flow can be measured with a first pass distribution analysis and the theoretical normal blood flow can be estimated from the total coronary arterial volume based on scaling laws. A computer simulation of the coronary arterial network was used to gain a better understanding of how hemodynamic conditions and coronary artery disease can affect blood flow, arterial volume and FFR estimation. Changes in coronary arterial flow and volume due to coronary stenosis, aortic pressure and venous pressure were examined to evaluate the potential use of flow and volume for FFR determination. This study showed that FFR can be estimated using arterial volume and a scaling coefficient corrected for aortic pressure. However, variations in venous pressure were found to introduce some error in FFR estimation. A relative form of FFR was introduced and was found to cancel out the influence of pressure on coronary flow, arterial volume and FFR estimation. The use of coronary flow and arterial volume for FFR determination appears promising. |
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Authors:
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Jerry T Wong; Sabee Molloi |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2008-07-03 |
Journal Detail:
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Title: Physics in medicine and biology Volume: 53 ISSN: 0031-9155 ISO Abbreviation: Phys Med Biol Publication Date: 2008 Jul |
Date Detail:
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Created Date: 2008-07-03 Completed Date: 2008-09-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0401220 Medline TA: Phys Med Biol Country: England |
Other Details:
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Languages: eng Pagination: 3995-4011 Citation Subset: IM |
Affiliation:
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Department of Radiological Sciences, University of California, Irvine, CA 92697, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure Blood Volume Computer Simulation Coronary Stenosis / physiopathology* Coronary Vessels / pathology, physiology, physiopathology Disease Models, Animal Models, Biological* Vasodilation |
| Grant Support | |
ID/Acronym/Agency:
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R01 HL67159/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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