| Determination of fluoride and chlorhexidine from chlorhexidine/fluoride-containing dentifrices. | |
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MedLine Citation:
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PMID: 292158 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The intention of the present experiment was to study the effects of a possible interaction between fluoride and chlorhexidine when both agents were incorporated in the same vehicle. The amount of fluoride extractable from dentrifrices containing 0.1% NaF and the fluoride ion activity were not reduced by the addition of 2% chlorhexidine digluconate. Less than 50% of the added chlorhexidine was available when the dentifrices were dissolved in deionized water. This was not affected by the presence of fluoride. The in vitro antibacterial activity of the chlorhexidine-containing dentifrices was not reduced by the addition of fluoride. Approximately 40% of the chlorhexidine was retained in the human oral cavity after brushing for 1 min with both the chlorhexidine- and the chlorhexidine/fluoride-containing dentifrice. Thus the binding of chlorhexidine to vehicle ingredients when dissolved in water is probably too weak to affect the retention in the mouth. |
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Authors:
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O K Dolles; P Bonesvoll; O N Gamst; P Gjermo |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Scandinavian journal of dental research Volume: 87 ISSN: 0029-845X ISO Abbreviation: Scand J Dent Res Publication Date: 1979 Apr |
Date Detail:
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Created Date: 1980-01-19 Completed Date: 1980-01-19 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0270023 Medline TA: Scand J Dent Res Country: DENMARK |
Other Details:
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Languages: eng Pagination: 115-22 Citation Subset: D; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Bacteria
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drug effects Chlorhexidine / analysis*, pharmacology Dentifrices / analysis* Drug Interactions Fluorides, Topical / analysis*, pharmacology Humans Microbial Sensitivity Tests Mouth Mucosa / metabolism Saliva / microbiology |
| Chemical | |
Reg. No./Substance:
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0/Dentifrices; 0/Fluorides, Topical; 55-56-1/Chlorhexidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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