Document Detail


Determination of fetal lung maturity from amniotic fluid microviscosity in high-risk pregnancy.
MedLine Citation:
PMID:  7070735     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
During a 3-year period, 377 samples of amniotic fluid, free of blood and meconium and obtained from a total of 471 patients, were examined by the fluorescence polarization technique to estimate fetal lung maturity. Fluorescence polarization values of 287 samples from normal and abnormal pregnancies were correlated with gestational age. A total of 272 pregnancies comprising cases complicated by toxemia, placental insufficiency, placenta previa, premature contractions, and diabetes mellitus, and including a control group of 37, were studied to discern the effect of such pathologic conditions on the usual decline of fluorescence polarization (FP) values with increasing gestational age. No complicated pregnancy had values significantly different from those of the control group, except for pregnancies complicated by diabetes mellitus. The threshold of fetal lung maturity as related to respiratory distress syndrome (RDS) was determined in correlation with the lecithin: sphingomyelin (L:S) ratio. FP values of 0.311 +/- .005 corresponded to an L:S ratio of 2.0. An FP value of 0.316 +/- .005 is recommended as a practical threshold related to the clinical outcome of the newborn as regards RDS. The technique was found reliable, simple, and accurate and has been of great value in the antenatal diagnosis of fetal lung maturity.
Authors:
G Barkai; S Mashiach; D Lanzer; Z Kayam; M Brish; B Goldman
Related Documents :
1173325 - Changes in amniotic fluid lecithin-sphingomyelin ratio following maternal dexamethasone...
9570025 - Fetal sex and variations in kinetic properties of neutrophil alkaline phosphatase durin...
1107905 - Placenta percreta.
6671325 - Ultrasound placental study and fetal lung maturity.
15283055 - Autologous endometrial coculture in patients with ivf failure: outcome of the first 1,0...
11006045 - Endometrial carcinoma remaining after term pregnancy following conservative treatment w...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  59     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  1982 May 
Date Detail:
Created Date:  1982-06-24     Completed Date:  1982-06-24     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  615-23     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Amniotic Fluid / analysis*
Female
Fetal Organ Maturity*
Gestational Age
Humans
Infant, Newborn
Lung / embryology*
Microscopy, Polarization
Phosphatidylcholines / analysis
Pregnancy
Pregnancy Complications
Respiratory Distress Syndrome, Newborn / diagnosis
Sphingomyelins / analysis
Viscosity
Chemical
Reg. No./Substance:
0/Phosphatidylcholines; 0/Sphingomyelins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Recurrence rate of ABO hemolytic disease of the newborn.
Next Document:  Fetal growth and perinatal viability in California.