Document Detail

Determination of fetal lung maturity from amniotic fluid microviscosity in high-risk pregnancy.
MedLine Citation:
PMID:  7070735     Owner:  NLM     Status:  MEDLINE    
During a 3-year period, 377 samples of amniotic fluid, free of blood and meconium and obtained from a total of 471 patients, were examined by the fluorescence polarization technique to estimate fetal lung maturity. Fluorescence polarization values of 287 samples from normal and abnormal pregnancies were correlated with gestational age. A total of 272 pregnancies comprising cases complicated by toxemia, placental insufficiency, placenta previa, premature contractions, and diabetes mellitus, and including a control group of 37, were studied to discern the effect of such pathologic conditions on the usual decline of fluorescence polarization (FP) values with increasing gestational age. No complicated pregnancy had values significantly different from those of the control group, except for pregnancies complicated by diabetes mellitus. The threshold of fetal lung maturity as related to respiratory distress syndrome (RDS) was determined in correlation with the lecithin: sphingomyelin (L:S) ratio. FP values of 0.311 +/- .005 corresponded to an L:S ratio of 2.0. An FP value of 0.316 +/- .005 is recommended as a practical threshold related to the clinical outcome of the newborn as regards RDS. The technique was found reliable, simple, and accurate and has been of great value in the antenatal diagnosis of fetal lung maturity.
G Barkai; S Mashiach; D Lanzer; Z Kayam; M Brish; B Goldman
Related Documents :
21277455 - Infiltrative lung diseases in pregnancy.
6671325 - Ultrasound placental study and fetal lung maturity.
15061315 - The effect of clinical characteristics on the lecithin/sphingomyelin ratio and lamellar...
3963425 - The development of the ovine small intestine.
23130975 - Sick leave during pregnancy: a longitudinal study of rates and risk factors in a norweg...
19261475 - Von hippel-lindau disease in pregnancy: a brief review.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  59     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  1982 May 
Date Detail:
Created Date:  1982-06-24     Completed Date:  1982-06-24     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  615-23     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Amniotic Fluid / analysis*
Fetal Organ Maturity*
Gestational Age
Infant, Newborn
Lung / embryology*
Microscopy, Polarization
Phosphatidylcholines / analysis
Pregnancy Complications
Respiratory Distress Syndrome, Newborn / diagnosis
Sphingomyelins / analysis
Reg. No./Substance:
0/Phosphatidylcholines; 0/Sphingomyelins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Recurrence rate of ABO hemolytic disease of the newborn.
Next Document:  Fetal growth and perinatal viability in California.