| Determination of fenoterol and salbutamol in pharmaceutical formulations by electrogenerated chemiluminescence. | |
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MedLine Citation:
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PMID: 19071827 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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Fenoterol and salbutamol were determined by electrogenerated chemiluminescence (ECL) coupled with flow injection analysis (FIA), using Ru(bpy)(3)(2+) as the luminescent substance. Fenoterol and salbutamol oxidize together with the ruthenium 2,2-bipyridyl at a platinum electrode, which leads to an increase in the luminescent intensity, and this increase is proportional to the analyte concentration. For fenoterol a linear calibration curve within the range from 1.0x10(-5) to 1.0x10(-4)mol l(-1) was obtained with a correlation coefficient of 0.998 (n=5) and for salbutamol the linear analytical curve was also obtained in this range with a correlation coefficient of 0.995 (n=5). The relative standard deviation was estimated as < or =2.5% for 3x10(-5)mol l(-1) for fenoterol solution and as < or =1.3% for 5.0x10(-5)mol l(-1) salbutamol solution for 15 successive injections. The limit of detection for fenoterol was 2.4x10(-7)mol l(-1) and for salbutamol was 4.0x10(-7)mol l(-1). Fenoterol and salbutamol were successfully determined in drug tablets and the soluble components of the matrix did not interfere in the luminescent emission. The results obtained using the luminescent methodology were not statistically different from those obtained by UV-spectrophotometry at 95% confidence level. |
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Authors:
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Cleber Antonio Lindino; Lu??s Ot??vio S Bulh??es |
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Publication Detail:
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Type: Journal Article Date: 2007-02-20 |
Journal Detail:
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Title: Talanta Volume: 72 ISSN: 1873-3573 ISO Abbreviation: Talanta Publication Date: 2007 Jul |
Date Detail:
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Created Date: 2008-12-16 Completed Date: 2009-12-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 2984816R Medline TA: Talanta Country: England |
Other Details:
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Languages: eng Pagination: 1746-51 Citation Subset: - |
Affiliation:
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Departamento de Qu??mica, LIEC, Universidade Federal de S??o Carlos, P.O. Box 676, 13565-905 S??o Carlos, SP, Brazil. lindino@unioeste.br |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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