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Determination of factors affecting glutamate concentrations in the whole blood of healthy human volunteers.
MedLine Citation:
PMID:  21248494     Owner:  NLM     Status:  In-Data-Review    
BACKGROUND: Abnormally high concentrations of glutamate in brain fluids have been shown to be neurotoxic and correlate with a poor neurological outcome following traumatic brain injury (TBI). Since brain fluid glutamate can be reduced by scavenging blood glutamate, the purpose of this study was to investigate factors that may potentially influence levels of blood glutamate, glucose, and the enzymes glutamate-pyruvate transaminase (GPT) and glutamate-oxaloacetate transaminase (GOT) in healthy individuals.
METHODS: Factors that were examined included age, gender, time of last meal or drink, and recent consumption of coffee. A total of 112 healthy volunteers between 18 and 70 years of age participated in the study. The average participant was 38 years old, and the sample consisted of 48 males and 64 females. Five milliliters of venous blood was collected from participants' cubital vein and blood glutamate, glucose, GOT and GPT levels were determined. Participants were then asked to complete a questionnaire addressing their gender, age, time of last meal, time of last drink, and whether coffee was consumed within the last 6 hours.
RESULTS: Blood glutamate concentrations were significantly higher in males than in females (P<0.001) and may be due to effects of estrogen and progesterone. Concentrations of GOT were significantly higher in males than in females (P<0.01). Concentrations of GPT were significantly higher in males than in females (P<0.01). There were no other significant differences demonstrated.
CONCLUSIONS: Understanding the factors that affect blood glutamate levels may give new insight into mechanisms that protect the brain from excess glutamate and result in a better neurological outcome following TBI.
Alexander Zlotnik; Sharon Ohayon; Benjamin F Gruenbaum; Shaun E Gruenbaum; Boaz Mohar; Matthew Boyko; Yael Klin; Eyal Sheiner; Gad Shaked; Yoram Shapira; Vivian I Teichberg
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of neurosurgical anesthesiology     Volume:  23     ISSN:  1537-1921     ISO Abbreviation:  J Neurosurg Anesthesiol     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-01-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8910749     Medline TA:  J Neurosurg Anesthesiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  45-9     Citation Subset:  IM    
Departments of *Anesthesiology and Critical Care §Obstetrics and Gynecology, Soroka Medical Center, Ben Gurion University ∥Department of General Surgery, Soroka University Medical Center, Beer Sheva ‡Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel †Department of Anesthesiology, Yale University School of Medicine, New Haven, CT.
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