Document Detail

Determination of ethoxyquin by high-performance liquid chromatography with fluorescence detection and its application to the survey of residues in food products of animal origin.
MedLine Citation:
PMID:  20334189     Owner:  NLM     Status:  MEDLINE    
An analytical method using HPLC with fluorescence detection (HPLC-FL) has been developed and applied for the survey of residue levels of ethoxyquin in a variety of food products of animal origin. HPLC was performed using a silica octadecylsilane column, butylhydroxytoluene-acetonitrile-water (0.05 + 800 + 200, v/v/v) mobile phase, and detection at excitation and emission wavelengths of 370 and 415 nm, respectively. HPLC/MS was used to confirm whether a chromatographic peak was ethoxyquin. The LOQ of the foods was 0.01 microg/g, except for pig fat and cow's milk, and the RSD (n=6) at 0.1 microg/mL of the standard solution was 1.12%. The accuracy of the calculated data of the standard solution was within the range of 94.0 to 101.2%. Recoveries of ethoxyquin from the food products of cattle, pigs, chickens, and salmon were more than 71.0% with an RSD of < 9.3%, except for chicken liver at different concentration levels, including the lower LOQ, the maximum residue limit (MRL), and in some tissues, twice the MRL. Residue levels of ethoxyquin in 33 commercially available food products of animal origin that were purchased on the west side of the Tokyo metropolitan area were surveyed. Contents of ethoxyquin residues in three chicken fat samples by the HPLC-FL method were 0.08, 0.03, and 0.04 microg/g, all less than the MRL (5 microg/g).
Yoichi Aoki; Akira Kotani; Naomi Miyazawa; Kazunari Uchida; Yu Igarashi; Norio Hirayama; Hideki Hakamata; Fumiyo Kusu
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of AOAC International     Volume:  93     ISSN:  1060-3271     ISO Abbreviation:  J AOAC Int     Publication Date:    2010 Jan-Feb
Date Detail:
Created Date:  2010-03-25     Completed Date:  2010-05-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9215446     Medline TA:  J AOAC Int     Country:  United States    
Other Details:
Languages:  eng     Pagination:  277-83     Citation Subset:  IM    
Research Institute for Animal Science in Biochemistry and Toxicology, Department of Analytical Chemistry, 3-7-11 Hashimotodai, Sagamihara, Kanagawa 229-1132, Japan.
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MeSH Terms
Chromatography, High Pressure Liquid / methods*
Drug Residues / analysis*
Eggs / analysis
Ethoxyquin / analysis*
Food Contamination / analysis*
Food Preservatives / analysis*
Liver / chemistry
Maximum Allowable Concentration
Meat / analysis
Milk / chemistry
Spectrometry, Fluorescence
Spectrometry, Mass, Electrospray Ionization
Sus scrofa
Reg. No./Substance:
0/Food Preservatives; 91-53-2/Ethoxyquin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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