Document Detail


Determination of dipyridamole in pharmaceutical preparations using square wave voltammetry.
MedLine Citation:
PMID:  15620540     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
An analytical methodology using square wave voltammetry (SWV) at a hanging mercury drop electrode (HMDE) was developed for the quantitative determination of dipyridamole (DIP), a drug used for the treatment of several cardiovascular diseases, in pharmaceutical tablets and injections of Persantin in phosphate buffer (pH 3.0; 0.1M). After optimization of the parameters for SWV, analytical curves were obtained for application in the range of 1.28 x 10(-6)M to 7.02 x 10(-6)M. It was found a detection limit (DL) of 1.88 x 10(-8)M (9.50 ng/ml). The repeatability and the reproducibility of the method were determinated by successive measurements of DIP solutions on the range of the analytical curve with a coefficient variation of 0.97% (n=5) and 1.15%, respectively. The apparent recoveries were obtained by the IUPAC recommended procedure using the second reduction peak. Recoveries obtained by SWV were compared with the UV-vis spectrophotometric method. It was found that the determination of DIP in Persantin tablets gave a mean value of 75.6+/-0.4 mg (100.8%) and 68.9+/-0.3 mg (91.8%) for SWV and UV-vis spectrophotometry, respectively. In the case of injections, it was found 10.4+/-0.1 mg (103.4%) and 9.9+/-0.2 mg (99.9%) for SWV and UV-vis spectrophotometry. Both apparent recoveries for the two types of formulations are in good accordance with the declared value of 75 mg (tablets) and 10 mg (injections).
Authors:
Renata Alves de Toledo; Marilza Castilho; Luiz Henrique Mazo
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pharmaceutical and biomedical analysis     Volume:  36     ISSN:  0731-7085     ISO Abbreviation:  J Pharm Biomed Anal     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2004-12-28     Completed Date:  2005-06-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8309336     Medline TA:  J Pharm Biomed Anal     Country:  England    
Other Details:
Languages:  eng     Pagination:  1113-7     Citation Subset:  IM    
Affiliation:
Instituto de Química de São Carlos, Universidade de São Paulo, Departmentamento de Fisico-Quimica, Avenida Trabalhador Sãocarlense, CP 780, 13560-970 São Carlos SP, Brazil.
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MeSH Terms
Descriptor/Qualifier:
Chemistry, Pharmaceutical / methods*
Dipyridamole / analysis*
Electrochemistry / methods
Pharmaceutical Preparations / analysis
Spectrophotometry, Ultraviolet / methods
Chemical
Reg. No./Substance:
0/Pharmaceutical Preparations; 58-32-2/Dipyridamole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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