Document Detail


Determination of degradation products from the calcium-channel blocker isradipine.
MedLine Citation:
PMID:  10096828     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Mass Spectrometry has been used to determine the identity of a number of degradation products from the bulk drug form of Isradipine (DynaCirc). Liquid chromatography coupled with mass spectrometry (LC/MS) was used to analyze the degraded samples and tentative identifications were made based upon the known reactivity of the molecule, molecular weight measurements and mass spectral fragmentation patterns. Isradipine was found to be stable to heating, acidic and basic conditions, but susceptible to degradation from exposure to UV light and oxidative processes.
Authors:
M G Bartlett; J C Spell; P S Mathis; M F Elgany; B E El Zeany; M A Elkawy; J T Stewart
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pharmaceutical and biomedical analysis     Volume:  18     ISSN:  0731-7085     ISO Abbreviation:  J Pharm Biomed Anal     Publication Date:  1998 Nov 
Date Detail:
Created Date:  1999-06-22     Completed Date:  1999-06-22     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8309336     Medline TA:  J Pharm Biomed Anal     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  335-45     Citation Subset:  IM    
Affiliation:
Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, The University of Georgia, Athens 30602-2352, USA. bartlett@rx.uga.edu
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MeSH Terms
Descriptor/Qualifier:
Calcium Channel Blockers / chemistry*
Gas Chromatography-Mass Spectrometry
Hot Temperature
Hydrogen Peroxide / chemistry*
Isradipine / chemistry*,  metabolism
Molecular Weight
Oxidation-Reduction
Ultraviolet Rays
Chemical
Reg. No./Substance:
0/Calcium Channel Blockers; 75695-93-1/Isradipine; 7722-84-1/Hydrogen Peroxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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