| Determination of cytotoxicity of nephrotoxins on murine and human kidney cell lines. | |
MedLine Citation:
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PMID: 18161576 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The present study investigates renal inner medullary collecting duct (mIMCD3) cells and human embryonic kidney cells (HEK293) for evaluation of cytotoxicity of nephrotoxic compounds. The 24 h LC(50) values for cisplatin, paraquat and ibuprofen in mIMCD3 cells were 135, 155 and 3600 microM, respectively. The 24 h LC(50) values for paraquat and ibuprofen in HEK293 cells were 180 and 1000 microM, respectively. Effects of hyperosmolality on cytotoxicity of paraquat were additive in mIMCD3 cells. These data demonstrate that renal hyperosmolality has an additive effect on cytoxicity of paraquat. |
Authors:
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Eun-Kee Park; Sally K Mak; Dietmar Kültz; Bruce D Hammock |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes Volume: 43 ISSN: 0360-1234 ISO Abbreviation: J Environ Sci Health B Publication Date: 2008 Jan |
Date Detail:
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Created Date: 2007-12-28 Completed Date: 2008-04-07 Revised Date: 2009-07-21 |
Medline Journal Info:
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Nlm Unique ID: 7607167 Medline TA: J Environ Sci Health B Country: United States |
Other Details:
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Languages: eng Pagination: 71-4 Citation Subset: IM |
Affiliation:
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Department of Entomology and Cancer Research Center, University of California-Davis, CA, USA. eunkee.park@ddb.nsw.gov.au |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Line Cell Survival / drug effects* Cisplatin / toxicity* Dose-Response Relationship, Drug Humans Ibuprofen / toxicity* Kidney / cytology*, drug effects* Kidney Medulla / cytology, drug effects Kidney Tubules, Collecting / cytology, drug effects Lethal Dose 50 Mice Osmolar Concentration Paraquat / toxicity* |
| Grant Support | |
ID/Acronym/Agency:
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P30 ES 05707/ES/NIEHS NIH HHS; P42 ES 04699/ES/NIEHS NIH HHS; R01 DK 59470/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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15663-27-1/Cisplatin; 15687-27-1/Ibuprofen; 4685-14-7/Paraquat |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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