Document Detail


Determination of cytotoxicity of nephrotoxins on murine and human kidney cell lines.
MedLine Citation:
PMID:  18161576     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The present study investigates renal inner medullary collecting duct (mIMCD3) cells and human embryonic kidney cells (HEK293) for evaluation of cytotoxicity of nephrotoxic compounds. The 24 h LC(50) values for cisplatin, paraquat and ibuprofen in mIMCD3 cells were 135, 155 and 3600 microM, respectively. The 24 h LC(50) values for paraquat and ibuprofen in HEK293 cells were 180 and 1000 microM, respectively. Effects of hyperosmolality on cytotoxicity of paraquat were additive in mIMCD3 cells. These data demonstrate that renal hyperosmolality has an additive effect on cytoxicity of paraquat.
Authors:
Eun-Kee Park; Sally K Mak; Dietmar Kültz; Bruce D Hammock
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes     Volume:  43     ISSN:  0360-1234     ISO Abbreviation:  J Environ Sci Health B     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2007-12-28     Completed Date:  2008-04-07     Revised Date:  2009-07-21    
Medline Journal Info:
Nlm Unique ID:  7607167     Medline TA:  J Environ Sci Health B     Country:  United States    
Other Details:
Languages:  eng     Pagination:  71-4     Citation Subset:  IM    
Affiliation:
Department of Entomology and Cancer Research Center, University of California-Davis, CA, USA. eunkee.park@ddb.nsw.gov.au
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Line
Cell Survival / drug effects*
Cisplatin / toxicity*
Dose-Response Relationship, Drug
Humans
Ibuprofen / toxicity*
Kidney / cytology*,  drug effects*
Kidney Medulla / cytology,  drug effects
Kidney Tubules, Collecting / cytology,  drug effects
Lethal Dose 50
Mice
Osmolar Concentration
Paraquat / toxicity*
Grant Support
ID/Acronym/Agency:
P30 ES 05707/ES/NIEHS NIH HHS; P42 ES 04699/ES/NIEHS NIH HHS; R01 DK 59470/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
15663-27-1/Cisplatin; 15687-27-1/Ibuprofen; 4685-14-7/Paraquat

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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