| Determination of coronary zero flow pressure by analysis of the baseline pressure-flow relationship in humans. | |
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MedLine Citation:
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PMID: 11548878 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The present study seeks to estimate the difference between coronary zero flow pressure (Pzf) by analysis of the baseline pressure-flow relationship and the Pzf calculated during a long diastole in humans. Although Pzf is likely to provide meaningful information about the characteristics of coronary circulation, there are no available data on Pzf in humans because Pzf is overestimated when it is calculated during normal cardiac cycles. Actual Pzf was determined in 15 subjects by analyzing the coronary pressure-flow relationship during a long cardiac cycle induced by an intracoronary adenosine triphosphate (ATP) infusion, and it was compared with the Pzf calculated during a normal cardiac cycle in order to estimate the difference. Pzf calculated during a normal cardiac cycle was 47 +/- 15 mmHg, which decreased to 36 +/- 9mmHg after intracoronary administration of ATP (0.05 mg) whereas actual Pzf was 21 +/- 7 mmHg. Pzf calculated in a pressure-flow relationship during a normal cardiac cycle under vasodilation correlated well with that during a long diastole (r = 0.75, p < 0.01), although it was 15 +/- 6 mmHg greater than the actual Pzf. It was concluded that Pzf during a normal cardiac cycle could be used to anticipate Pzf. |
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Authors:
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S Nanto; T Masuyama; Y Takano; M Hori; S Nagata |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Japanese circulation journal Volume: 65 ISSN: 0047-1828 ISO Abbreviation: Jpn. Circ. J. Publication Date: 2001 Sep |
Date Detail:
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Created Date: 2001-09-10 Completed Date: 2002-09-16 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7806868 Medline TA: Jpn Circ J Country: Australia |
Other Details:
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Languages: eng Pagination: 793-6 Citation Subset: IM |
Affiliation:
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Cardiovascular Division of Kansai Rosai Hospital, Amagasaki, Japan. AC6S-NNT@asahi-net.or.jp |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine Triphosphate
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administration & dosage,
pharmacology Adult Aged Blood Pressure / drug effects, physiology Coronary Circulation / drug effects, physiology* Female Humans Male Middle Aged Models, Cardiovascular* Regional Blood Flow / drug effects, physiology Vascular Resistance |
| Chemical | |
Reg. No./Substance:
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56-65-5/Adenosine Triphosphate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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