Document Detail

Determination of cell fates in the R7 equivalence group of the Drosophila eye by the concerted regulation of D-Pax2 and TTK88.
MedLine Citation:
PMID:  19406115     Owner:  NLM     Status:  MEDLINE    
In the developing Drosophila eye, the precursors of the neuronal photoreceptor cells R1/R6/R7 and non-neuronal cone cells share the same developmental potential and constitute the R7 equivalence group. It is not clear how cells of this group elaborate their distinct fates. Here we show that both TTK88 and D-Pax2 play decisive roles in cone cell development and act in concert to transform developing R1/R6/R7 into cone cells: while TTK88 blocks neuronal development, D-Pax2 promotes cone cell specification. In addition, ectopic TTK88 in R cells induces apoptosis, which is suppressed by ectopic D-Pax2. We further demonstrate that Phyllopod (Phyl), previously shown to promote the neuronal fate in R1/R6/R7 by targeting TTK for degradation, also inhibits D-Pax2 transcription to prevent cone cell specification. Thus, the fates of R1/R6/R7 and cone cells are determined by a dual mechanism that coordinately activates one fate while inhibiting the other.
Yandong Shi; Markus Noll
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Publication Detail:
Type:  Journal Article     Date:  2009-05-03
Journal Detail:
Title:  Developmental biology     Volume:  331     ISSN:  1095-564X     ISO Abbreviation:  Dev. Biol.     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-06-08     Completed Date:  2009-07-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372762     Medline TA:  Dev Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  68-77     Citation Subset:  IM    
Institute for Molecular Biology, University of Zürich, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland.
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MeSH Terms
Drosophila / genetics*
Drosophila Proteins / metabolism*
Eye / growth & development*,  ultrastructure
Gene Expression Regulation, Developmental
Larva / physiology
Microscopy, Electron, Scanning
Neurons / physiology
PAX2 Transcription Factor / genetics*,  metabolism
Photoreceptor Cells / physiology
Pupa / physiology
Repressor Proteins / metabolism*
Retinal Cone Photoreceptor Cells / cytology,  physiology*,  ultrastructure
Reg. No./Substance:
0/Drosophila Proteins; 0/PAX2 Transcription Factor; 0/Repressor Proteins; 0/ttk protein, Drosophila

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