Document Detail

Determination of cardiac output by the Fick method, thermodilution, and acetylene rebreathing in pulmonary hypertension.
MedLine Citation:
PMID:  10430725     Owner:  NLM     Status:  MEDLINE    
Assessment of cardiac output is an important part of the management of patients with pulmonary hypertension. The accuracy of the thermodilution technique in patients with low cardiac output or severe tricuspid regurgitation has been questioned. To address this issue, we simultaneously compared 105 cardiac output measurements by the Fick method and thermodilution in 35 patients with pulmonary hypertension. Moreover, we evaluated the acetylene rebreathing technique, a noninvasive method of determining cardiac output. The mean difference +/- 95% limit of agreement between thermodilution and the Fick method was +0.01 +/- 1.1 L/min. The mean difference +/- 95% limit of agreement between acetylene rebreathing and the Fick method was -0.23 +/- 1.14 L/min. Neither the mean agreement nor the 95% limits of agreement of both thermodilution and acetylene rebreathing with the Fick method were affected by the presence of low cardiac output or severe tricuspid regurgitation. We conclude that thermodilution and acetylene rebreathing are useful tools for assessing cardiac output in patients with pulmonary hypertension, even in the presence of low cardiac output or severe tricuspid regurgitation.
M M Hoeper; R Maier; J Tongers; J Niedermeyer; J M Hohlfeld; M Hamm; H Fabel
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  American journal of respiratory and critical care medicine     Volume:  160     ISSN:  1073-449X     ISO Abbreviation:  Am. J. Respir. Crit. Care Med.     Publication Date:  1999 Aug 
Date Detail:
Created Date:  1999-08-30     Completed Date:  1999-08-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9421642     Medline TA:  Am J Respir Crit Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  535-41     Citation Subset:  AIM; IM    
Department of Respiratory Medicine, Hannover Medical School, Hannover, Germany.
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MeSH Terms
Acetylene / diagnostic use*
Blood Gas Analysis*
Cardiac Output / physiology
Cardiac Output, Low / diagnosis*,  physiopathology
Hypertension, Pulmonary / diagnosis*,  physiopathology
Middle Aged
Respiratory Mechanics / physiology
Sensitivity and Specificity
Tricuspid Valve Insufficiency / diagnosis,  physiopathology
Reg. No./Substance:

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