| Determination of cardiac involvement in sarcoidosis by magnetic resonance imaging and Doppler echocardiography. | |
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MedLine Citation:
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PMID: 12528765 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To elucidate whether cardiac magnetic resonance imaging (MRI) could be useful in disclosing structural changes in the myocardium in sarcoidosis patients and to relate echo-Doppler derived indices of left ventricular function to electrocardiogram (ECG) findings. DESIGN: The MRI was performed in 18 consecutive patients with sarcoidosis. Left ventricular ejection fraction (LVEF), i.e. systolic function, was estimated echocardiographically by Simpson's two-dimensional method (n = 16). Diastolic function was estimated by age-corrected Doppler-derived indices: isovolumetric relaxation time (IVRT), deceleration time (DT) and early filling/atrial contraction ratio (E/A ratio). RESULTS: Eleven patients had conduction defects or dysrhythmias (ECG+) whilst seven patients had a normal ECG (ECG-). In two patients, high signalling, contrast-enhanced, isolated regions, suggestive of deposits, were seen in the left ventricular myocardium on MRI. Both these patients had abnormal ECGs and signs of systolic and/or diastolic dysfunction on echocardiography. LVEF was subnormal in seven of 10 of the ECG+ patients and in two of six of the ECG-. Signs of diastolic dysfunction were found in 59% and 56% of the measurements in the ECG+ and ECG- patients, respectively. CONCLUSION: We conclude (i) that myocardial deposits on MRI in sarcoidosis patients have a high specificity for cardiac involvement but a rather low sensitivity; (ii) that a substantial proportion of sarcoidosis patients with abnormal ECGs have echocardiographic signs of systolic and/or diastolic dysfunction. |
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Authors:
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C M Sköld; F F Larsen; E Rasmussen; S K Pehrsson; A G Eklund |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of internal medicine Volume: 252 ISSN: 0954-6820 ISO Abbreviation: J. Intern. Med. Publication Date: 2002 Nov |
Date Detail:
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Created Date: 2003-01-16 Completed Date: 2003-02-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8904841 Medline TA: J Intern Med Country: England |
Other Details:
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Languages: eng Pagination: 465-71 Citation Subset: IM |
Affiliation:
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Division of Respiratory Medicine, Department of Medicine, Karolinska Hospital and Institutet, Stockholm, Sweden. magnus.skold@ks.se |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Cardiomyopathies / diagnosis* Echocardiography, Doppler / methods Female Humans Magnetic Resonance Angiography / methods Male Middle Aged Sarcoidosis / diagnosis* |
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