| Determination of the brain-blood partition coefficient for water in mice using MRI. | |
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MedLine Citation:
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PMID: 20842161 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cerebral blood flow (CBF) quantification is a valuable tool in stroke research. Mice are of special interest because of the potential of genetic engineering. Magnetic resonance imaging (MRI) provides repetitive, noninvasive CBF quantification. Many MRI techniques require the knowledge of the brain-blood partition coefficient (BBPC) for water. Adopting an MRI protocol described by Roberts et al (1996) in humans, we determined the BBPC for water in 129S6/SvEv mice from proton density measurements of brain and blood, calibrated with deuterium oxide/water phantoms. The average BBPC for water was 0.89 ± 0.03 mL/g, with little regional variation within the mouse brain. |
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Authors:
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Christoph Leithner; Susanne Müller; Martina Füchtemeier; Ute Lindauer; Ulrich Dirnagl; Georg Royl |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-09-15 |
Journal Detail:
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Title: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Volume: 30 ISSN: 1559-7016 ISO Abbreviation: J. Cereb. Blood Flow Metab. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-02 Completed Date: 2010-11-29 Revised Date: 2011-11-01 |
Medline Journal Info:
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Nlm Unique ID: 8112566 Medline TA: J Cereb Blood Flow Metab Country: United States |
Other Details:
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Languages: eng Pagination: 1821-4 Citation Subset: IM |
Affiliation:
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Department of Experimental Neurology, Charité-Universitätsmedizin, Center for Stroke Research Berlin, Berlin, Germany. christoph.leithner@charite.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood-Brain Barrier / metabolism* Brain / metabolism* Calibration Cerebrovascular Circulation* Deuterium Oxide / metabolism Female Magnetic Resonance Imaging* Male Mice Mice, Inbred Strains Phantoms, Imaging Protons Water / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Protons; 7732-18-5/Water; 7789-20-0/Deuterium Oxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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