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Determination of the antiulcer properties of sodium cromoglycate in pylorus-ligated albino rats.
MedLine Citation:
PMID:  20871772     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: To study the ulcer protective property of sodium cromoglycate in pylorusligated rats and the biochemical role in ulcer protection by various biochemical tests.
MATERIALS AND METHODS: The ulcer protective effect of sodium cromoglycate was studied using a Pyloric Ligation Model using Wistar albino rats. The antiulcer effect of sodium cromoglycate 40 mg/kg b.w., i.p., was compared with the reference drug ranitidine 27 mg/kg b.w., i.p. The ulcer index was calculated and other biochemical parameters like free acidity, total acidity, pH, mucin, pepsin and volume of gastric juice were determined.
RESULTS: Pylorus ligation showed a significant (P < 0.01) reduction in gastric volume, free acidity, total acidity and ulcer index as compared to the control.
CONCLUSION: Sodium cromoglycate has activity equipotent to ranitidine.
Authors:
Vivek Srivastava; A H M Viswanathaswamy; Govind Mohan
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Indian journal of pharmacology     Volume:  42     ISSN:  1998-3751     ISO Abbreviation:  Indian J Pharmacol     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-09-27     Completed Date:  2011-07-14     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  7902477     Medline TA:  Indian J Pharmacol     Country:  India    
Other Details:
Languages:  eng     Pagination:  185-8     Citation Subset:  -    
Affiliation:
Department of Pharmacology, KLE Society College of Pharmacy, Hubli, India.
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