| Determination of the antiulcer properties of sodium cromoglycate in pylorus-ligated albino rats. | |
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MedLine Citation:
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PMID: 20871772 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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OBJECTIVES: To study the ulcer protective property of sodium cromoglycate in pylorusligated rats and the biochemical role in ulcer protection by various biochemical tests. MATERIALS AND METHODS: The ulcer protective effect of sodium cromoglycate was studied using a Pyloric Ligation Model using Wistar albino rats. The antiulcer effect of sodium cromoglycate 40 mg/kg b.w., i.p., was compared with the reference drug ranitidine 27 mg/kg b.w., i.p. The ulcer index was calculated and other biochemical parameters like free acidity, total acidity, pH, mucin, pepsin and volume of gastric juice were determined. RESULTS: Pylorus ligation showed a significant (P < 0.01) reduction in gastric volume, free acidity, total acidity and ulcer index as compared to the control. CONCLUSION: Sodium cromoglycate has activity equipotent to ranitidine. |
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Authors:
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Vivek Srivastava; A H M Viswanathaswamy; Govind Mohan |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Indian journal of pharmacology Volume: 42 ISSN: 1998-3751 ISO Abbreviation: Indian J Pharmacol Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-09-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7902477 Medline TA: Indian J Pharmacol Country: India |
Other Details:
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Languages: eng Pagination: 185-8 Citation Subset: - |
Affiliation:
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Department of Pharmacology, KLE Society College of Pharmacy, Hubli, India. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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