Document Detail


Determination of antitubercular drugs in human plasma by HPLC through direct injection.
MedLine Citation:
PMID:  2088365     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A simple and efficient method is described for the direct determination of Isoniazide (INH) and Pyrazinamide (PZAm) in human plasma, based on reversed-phase HPLC. A number of other antitubercular drugs such as p-Aminosalycylic acid (PAS), Streptomycin (STM) and Ethambutol (ETH) and the major metabolites of the two investigated drugs, namely N-Monoacetylisoniazide (AcINH) and Pyrazinoic acid (PZAc), were shown not to interfere with the assay method. A potential application of the method to routine clinical monitoring of antitubercular drugs is discussed.
Authors:
C Altomare; A Carotti; S Cellamare; G Leogrande; D De Vito
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Farmaco (Società chimica italiana : 1989)     Volume:  45     ISSN:  0014-827X     ISO Abbreviation:  Farmaco     Publication Date:  1990 Nov 
Date Detail:
Created Date:  1991-05-29     Completed Date:  1991-05-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8912641     Medline TA:  Farmaco     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  1229-36     Citation Subset:  IM    
Affiliation:
Dipartimento Farmaco-Chimico, Università di Bari, Italy.
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MeSH Terms
Descriptor/Qualifier:
Antitubercular Agents / blood*
Biotransformation
Chromatography, High Pressure Liquid
Humans
Chemical
Reg. No./Substance:
0/Antitubercular Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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