| Determination of antitubercular drugs in human plasma by HPLC through direct injection. | |
MedLine Citation:
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PMID: 2088365 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A simple and efficient method is described for the direct determination of Isoniazide (INH) and Pyrazinamide (PZAm) in human plasma, based on reversed-phase HPLC. A number of other antitubercular drugs such as p-Aminosalycylic acid (PAS), Streptomycin (STM) and Ethambutol (ETH) and the major metabolites of the two investigated drugs, namely N-Monoacetylisoniazide (AcINH) and Pyrazinoic acid (PZAc), were shown not to interfere with the assay method. A potential application of the method to routine clinical monitoring of antitubercular drugs is discussed. |
Authors:
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C Altomare; A Carotti; S Cellamare; G Leogrande; D De Vito |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Farmaco (Società chimica italiana : 1989) Volume: 45 ISSN: 0014-827X ISO Abbreviation: Farmaco Publication Date: 1990 Nov |
Date Detail:
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Created Date: 1991-05-29 Completed Date: 1991-05-29 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8912641 Medline TA: Farmaco Country: ITALY |
Other Details:
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Languages: eng Pagination: 1229-36 Citation Subset: IM |
Affiliation:
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Dipartimento Farmaco-Chimico, Università di Bari, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antitubercular Agents
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blood* Biotransformation Chromatography, High Pressure Liquid Humans |
| Chemical | |
Reg. No./Substance:
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0/Antitubercular Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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