| Determination of anti-tumor agent bis(p-fluorobenzyl)trisulfide and its degraded compound in rat blood using reversed phase high-performance liquid chromatography. | |
| | |
MedLine Citation:
|
PMID: 18479981 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Bis(p-fluorobenzyl)trisulfide (BFTS) demonstrated a broad spectrum of anti-proliferative activity and in vivo anti-tumor efficacy in human xenograft mice models. BFTS is rapidly degraded to its major metabolite bis(p-fluorobenzyl)disulfide (BFDS) in blood. In this study, we developed a reliable procedure for stable storage and treatment of blood samples containing BFTS. An HPLC assay method was developed and validated for the quantitative determination of BFTS and BFDS in rat blood. The developed procedure and method have been successfully utilized to study the concentration-time curves of BFTS and BFDS in the blood of rats after vein injection of 12.5 mg kg(-1) BFTS. |
| | |
Authors:
|
Liqiang Gu; Liping Li; Zhongjian Chen; Hao Pan; Huidi Jiang; Su Zeng; Xiao Xu; Haoyun An |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Validation Studies Date: 2008-04-25 |
Journal Detail:
|
Title: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Volume: 868 ISSN: 1570-0232 ISO Abbreviation: J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. Publication Date: 2008 Jun |
Date Detail:
|
Created Date: 2008-06-03 Completed Date: 2008-08-18 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101139554 Medline TA: J Chromatogr B Analyt Technol Biomed Life Sci Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 77-82 Citation Subset: IM |
Affiliation:
|
Department of Pharmaceutical Analysis and Drug Metabolism, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Antineoplastic Agents / blood* Chromatography, High Pressure Liquid / methods* Fluorobenzenes / blood* Rats Rats, Sprague-Dawley Reproducibility of Results Sensitivity and Specificity Sulfides / blood* |
| Chemical | |
Reg. No./Substance:
|
0/Antineoplastic Agents; 0/Fluorobenzenes; 0/Sulfides; 0/fluorapacin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Both replication bypass fidelity and repair efficiency influence the yield of mutations per target d...
Next Document: Statins (HMG-coenzyme A reductase inhibitors)-biomimetic membrane binding mechanism investigated by ...