Document Detail

Determination of ampicillin and amoxycillin by flow injection chemiluminescence method based on their enhancing effects on the luminol-periodate reaction.
MedLine Citation:
PMID:  14694419     Owner:  NLM     Status:  MEDLINE    
In this work, a new flow injection chemiluminescence method is described for the determination of ampicillin and amoxycillin. The method is based on the strong enhancing effects of these antibiotics on the luminol-periodate reaction. The present method allows the measurements of ampicillin in the range 0.02-1.0 mg/L range and amoxycillin in the range 0.1-10.0 mg/L range with the relative standard deviations within 0.8-2.0%. The sampling frequency was calculated about 90/h. The method was successfully applied to the determination of ampicillin and amoxycillin in pharmaceutical preparations. A brief discussion on the possible chemiluminescence reaction mechanism is presented.
Yinhuan Li; Yuhai Tang; Hong Yao; Junmei Fu
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Luminescence : the journal of biological and chemical luminescence     Volume:  18     ISSN:  1522-7235     ISO Abbreviation:  Luminescence     Publication Date:    2003 Nov-Dec
Date Detail:
Created Date:  2003-12-24     Completed Date:  2004-10-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100889025     Medline TA:  Luminescence     Country:  England    
Other Details:
Languages:  eng     Pagination:  313-7     Citation Subset:  IM    
Copyright Information:
Copyright 2003 John Wiley & Sons, Ltd.
Department of Chemistry, School of Science, Xi'an Jiaotong University, 710049, People's Republic of China.
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MeSH Terms
Amoxicillin / analysis*
Ampicillin / analysis*
Anti-Bacterial Agents / analysis*
Chemiluminescent Measurements
Flow Injection Analysis / methods*
Indicators and Reagents
Luminol / chemistry*
Periodic Acid / chemistry*
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Indicators and Reagents; 10450-60-9/Periodic Acid; 26787-78-0/Amoxicillin; 521-31-3/Luminol; 69-53-4/Ampicillin; 7790-28-5/metaperiodate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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