Document Detail


Determination of amino acid pairs sensitive to variants in human copper-transporting ATPase 2.
MedLine Citation:
PMID:  15158437     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In this study, we use our probabilistic approach to analyze the amino acid pairs in human copper-transporting ATPase 2 (ATP7B) in order to determine which amino acid pairs are more sensitive to 125 variants from missense mutant human ATP7B. The results show 97.6% of 125 variants occur at randomly unpredictable amino acid pairs, which account for 80.9% of amino acid pairs in ATP7B, and the chance of occurring of variant is about 9 times higher in randomly unpredictable amino acid pairs than in predictable pairs. Thus, the randomly unpredictable amino acid pairs are more sensitive to variants in human ATP7B.
Authors:
Guang Wu; Shaomin Yan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  319     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  2004 Jun 
Date Detail:
Created Date:  2004-05-25     Completed Date:  2004-07-12     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  United States    
Other Details:
Languages:  eng     Pagination:  27-31     Citation Subset:  IM    
Affiliation:
DreamSciTech Consulting Co. Ltd., 301, Building 12, Nanyou A-zone, Jiannan Road, Shenzhen, Guangdong Province CN-518054, China. hongguanglishibahao@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Adenosine Triphosphatases / chemistry*,  genetics*
Amino Acids
Cation Transport Proteins / chemistry*,  genetics*
Computational Biology
Genetic Variation
Humans
Models, Statistical
Mutation
Mutation, Missense
Chemical
Reg. No./Substance:
0/Amino Acids; 0/Cation Transport Proteins; EC 3.6.1.-/Adenosine Triphosphatases; EC 3.6.3.4/Wilson disease protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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