| Determination of amino acid pairs sensitive to variants in human copper-transporting ATPase 2. | |
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MedLine Citation:
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PMID: 15158437 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In this study, we use our probabilistic approach to analyze the amino acid pairs in human copper-transporting ATPase 2 (ATP7B) in order to determine which amino acid pairs are more sensitive to 125 variants from missense mutant human ATP7B. The results show 97.6% of 125 variants occur at randomly unpredictable amino acid pairs, which account for 80.9% of amino acid pairs in ATP7B, and the chance of occurring of variant is about 9 times higher in randomly unpredictable amino acid pairs than in predictable pairs. Thus, the randomly unpredictable amino acid pairs are more sensitive to variants in human ATP7B. |
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Authors:
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Guang Wu; Shaomin Yan |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biochemical and biophysical research communications Volume: 319 ISSN: 0006-291X ISO Abbreviation: Biochem. Biophys. Res. Commun. Publication Date: 2004 Jun |
Date Detail:
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Created Date: 2004-05-25 Completed Date: 2004-07-12 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: United States |
Other Details:
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Languages: eng Pagination: 27-31 Citation Subset: IM |
Affiliation:
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DreamSciTech Consulting Co. Ltd., 301, Building 12, Nanyou A-zone, Jiannan Road, Shenzhen, Guangdong Province CN-518054, China. hongguanglishibahao@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine Triphosphatases
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chemistry*,
genetics* Amino Acids Cation Transport Proteins / chemistry*, genetics* Computational Biology Genetic Variation Humans Models, Statistical Mutation Mutation, Missense |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Cation Transport Proteins; EC 3.6.1.-/Adenosine Triphosphatases; EC 3.6.3.4/Wilson disease protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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