Document Detail


Determination of alphamethyldopa, dihydroxyphenylacetic acid and 5-hydroxyindolacetic acid in the cerebrospinal fluid of the rat: kinetic study.
MedLine Citation:
PMID:  6198176     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cerebrospinal fluid (CSF) was removed at a constant flow rate of 1 microliter min-1 from the third ventricle of rats and directly analyzed by liquid chromatography coupled with electrochemical detection. The effect of alphamethyldopa (alpha MD) on CSF alpha MD, dihydroxyphenylacetic acid (DOPAC) and 5-hydroxyindolacetic acid (5-HIAA) concentrations was studied for 5 h. alpha MD ethyl ester administration resulted in higher alpha MD levels in CSF as compared with alpha MD administration, suggesting a higher bioavailability of the ethyl ester vs the free acid. A specific inhibition of dopamine metabolism was reflected by a reduction in DOPAC levels while 5-HIAA concentrations were unchanged.
Authors:
J L Elghozi; D Laude; E Mignot; P Meyer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European heart journal     Volume:  4 Suppl G     ISSN:  0195-668X     ISO Abbreviation:  Eur. Heart J.     Publication Date:  1983 Nov 
Date Detail:
Created Date:  1984-03-23     Completed Date:  1984-03-23     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8006263     Medline TA:  Eur Heart J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  31-4     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
3,4-Dihydroxyphenylacetic Acid / cerebrospinal fluid*
Animals
Hydroxyindoleacetic Acid / cerebrospinal fluid*
Kinetics
Male
Methyldopa / cerebrospinal fluid*
Phenylacetates / cerebrospinal fluid*
Rats
Rats, Inbred Strains
Chemical
Reg. No./Substance:
0/Phenylacetates; 102-32-9/3,4-Dihydroxyphenylacetic Acid; 54-16-0/Hydroxyindoleacetic Acid; 555-30-6/Methyldopa

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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