| Determination of activities of levofloxacin, alone and combined with gentamicin, ceftazidime, cefpirome, and meropenem, against 124 strains of Pseudomonas aeruginosa by checkerboard and time-kill methodology. | |
| | |
MedLine Citation:
|
PMID: 9559819 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
A total of 124 Pseudomonas aeruginosa strains were tested for synergy between levofloxacin and cefpirome, ceftazidime, gentamicin, and meropenem. Checkerboards yielded synergistic fractional inhibitory concentration (FIC) indices (< or =0.5) with 25 of 496 possible combinations. All other FIC indices were >0.5 to 2 (additive or indifferent), with no antagonism. Time-kill studies with 12 strains showed that levofloxacin (0.06 to 0.5 microg/ml) was synergistic with cefpirome, ceftazidime, gentamicin, and meropenem in 10, 9, 4, and 11 strains, respectively. |
| | |
Authors:
|
M A Visalli; M R Jacobs; P C Appelbaum |
Related Documents
:
|
7592169 - A critical assessment of the agar dilution chequerboard technique for studying in-vitro... 7850199 - Resistance to aminoglycosides in pseudomonas. aminoglycoside resistance study groups. 6808909 - Examination of pseudomonas aeruginosa-gentamicin discrepancies encountered in an autoba... 1416839 - Increased resistance to amikacin in a neonatal unit following intensive amikacin usage. 9884829 - In vitro susceptibility and molecular analysis of gentamicin-resistant enterococci. 9163709 - Antibiotic sensitivity of isolates of pseudomonas aeruginosa in buraidah, saudi arabia. 19028619 - In vitro activity of tigecycline: mics, mbcs, time-kill curves and post-antibiotic effect. 19869569 - Studies on indifferent streptococci : iii. the allergizing capacity of different strains. 12773059 - Linezolid resistance since 2001: sentry antimicrobial surveillance program. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Antimicrobial agents and chemotherapy Volume: 42 ISSN: 0066-4804 ISO Abbreviation: Antimicrob. Agents Chemother. Publication Date: 1998 Apr |
Date Detail:
|
Created Date: 1998-06-22 Completed Date: 1998-06-22 Revised Date: 2013-04-18 |
Medline Journal Info:
|
Nlm Unique ID: 0315061 Medline TA: Antimicrob Agents Chemother Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 953-5 Citation Subset: IM |
Affiliation:
|
Department of Pathology (Clinical Microbiology), Hershey Medical Center, Pennsylvania 17033, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Anti-Bacterial Agents
/
pharmacology Anti-Infective Agents / pharmacology* Ceftazidime / pharmacology Cephalosporins / pharmacology Drug Resistance, Microbial Drug Synergism Drug Therapy, Combination / pharmacology* Gentamicins / pharmacology Microbial Sensitivity Tests Ofloxacin / pharmacology* Pseudomonas aeruginosa / drug effects* Thienamycins / pharmacology Time Factors |
| Chemical | |
Reg. No./Substance:
|
0/Anti-Bacterial Agents; 0/Anti-Infective Agents; 0/Cephalosporins; 0/Gentamicins; 0/Thienamycins; 78439-06-2/Ceftazidime; 82419-36-1/Ofloxacin; 84957-29-9/cefpirome; 96036-03-2/meropenem |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: In vitro activity of a new 8-methoxyquinolone, BAY 12-8039, against Chlamydia pneumoniae.
Next Document: Mutations in aarE, the ubiA homolog of Providencia stuartii, result in high-level aminoglycoside res...