Document Detail

Determination of activities of levofloxacin, alone and combined with gentamicin, ceftazidime, cefpirome, and meropenem, against 124 strains of Pseudomonas aeruginosa by checkerboard and time-kill methodology.
MedLine Citation:
PMID:  9559819     Owner:  NLM     Status:  MEDLINE    
A total of 124 Pseudomonas aeruginosa strains were tested for synergy between levofloxacin and cefpirome, ceftazidime, gentamicin, and meropenem. Checkerboards yielded synergistic fractional inhibitory concentration (FIC) indices (< or =0.5) with 25 of 496 possible combinations. All other FIC indices were >0.5 to 2 (additive or indifferent), with no antagonism. Time-kill studies with 12 strains showed that levofloxacin (0.06 to 0.5 microg/ml) was synergistic with cefpirome, ceftazidime, gentamicin, and meropenem in 10, 9, 4, and 11 strains, respectively.
M A Visalli; M R Jacobs; P C Appelbaum
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Antimicrobial agents and chemotherapy     Volume:  42     ISSN:  0066-4804     ISO Abbreviation:  Antimicrob. Agents Chemother.     Publication Date:  1998 Apr 
Date Detail:
Created Date:  1998-06-22     Completed Date:  1998-06-22     Revised Date:  2013-04-18    
Medline Journal Info:
Nlm Unique ID:  0315061     Medline TA:  Antimicrob Agents Chemother     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  953-5     Citation Subset:  IM    
Department of Pathology (Clinical Microbiology), Hershey Medical Center, Pennsylvania 17033, USA.
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MeSH Terms
Anti-Bacterial Agents / pharmacology
Anti-Infective Agents / pharmacology*
Ceftazidime / pharmacology
Cephalosporins / pharmacology
Drug Resistance, Microbial
Drug Synergism
Drug Therapy, Combination / pharmacology*
Gentamicins / pharmacology
Microbial Sensitivity Tests
Ofloxacin / pharmacology*
Pseudomonas aeruginosa / drug effects*
Thienamycins / pharmacology
Time Factors
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Anti-Infective Agents; 0/Cephalosporins; 0/Gentamicins; 0/Thienamycins; 78439-06-2/Ceftazidime; 82419-36-1/Ofloxacin; 84957-29-9/cefpirome; 96036-03-2/meropenem

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