| Determination of acetylsalicylic acid and metabolites in biological fluids by high-performance liquid chromatography. | |
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MedLine Citation:
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PMID: 6833429 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A new method has been developed for the determination of acetylsalicylic acid, salicylic acid, salicyluric acid and gentisic acid in plasma, urine and tissue homogenates by simple extraction with ethyl acetate, evaporation and redissolution and measuring by high-performance liquid chromatography. Linearity, reproducibility and recovery were determined. Experiments were carried out to investigate the decomposition of acetylsalicylic acid in plasma with fluoride at different temperatures. The method has been used for pharmacokinetic experiments and an example is given. |
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Authors:
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U Reidl |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of chromatography Volume: 272 ISSN: 0021-9673 ISO Abbreviation: J. Chromatogr. Publication Date: 1983 Feb |
Date Detail:
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Created Date: 1983-05-27 Completed Date: 1983-05-27 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0427043 Medline TA: J Chromatogr Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 325-31 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Aspirin / analysis, metabolism* Chromatography, High Pressure Liquid / methods Gentisates / analysis Hippurates / analysis Humans Kinetics Male Rabbits Salicylic Acid Salicylic Acids / analysis Specimen Handling |
| Chemical | |
Reg. No./Substance:
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0/Gentisates; 0/Hippurates; 0/Salicylic Acids; 487-54-7/salicylurate; 50-78-2/Aspirin; 69-72-7/Salicylic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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