Document Detail


Determination of Radioactivity in Infant, Juvenile and Adult Rat Brains after Injection of Anti-influenza Drug [(11)C]Oseltamivir Using PET and Autoradiography.
MedLine Citation:
PMID:  21443926     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Oseltamivir phosphate (Tamiflu(®)) is an orally active anti-influenza drug, which is hydrolyzed to its metabolite Ro 64-0802 inhibiting the influenza virus with potent activity. The abnormal behavior of young influenza patients associated with the use of oseltamivir has developed to a social problem in countries where Tamiflu is often prescribed. It is important to determine the amount of oseltamivir in the brain and to elucidate the relationship between its presence and neuropsychiatric side effects. The aim of this study was to determine the radioactivity in the infant, juvenile and adult rat brains after injection of [(11)C]oseltamivir into the rats using PET and autoradiography. After injection of this radioligand, the highest radioactivity was found in the infant brain and the radioactivity level decreased with age. Ex vivo autoradiography on the infant brain displayed a relatively higher radioactivity in the cerebellum than that in the cerebrum. Pretreatment with cyclosporin A (an inhibitor for P-glycoprotein) increased the brain radioactivity. These results give helpful insights into elucidating why the neuropsychiatric side effects of oseltamivir occur in young patients.
Authors:
Akiko Hatori; Joji Yui; Kazuhiko Yanamoto; Tomoteru Yamasaki; Kazunori Kawamura; Makoto Takei; Takuya Arai; Toshimitsu Fukumura; Ming-Rong Zhang
Related Documents :
6691296 - The relationship of birth size to the rate of growth in infancy and childhood.
17241766 - Relationship between weight, speaking fundamental frequency, and the appearance of phon...
853336 - Kwashiorkor not associated with poverty.
21414006 - Thomsen-friedenreich activation in infants with necrotizing enterocolitis in taiwan.
22184646 - Impact of a transcutaneous bilirubinometry program on resource utilization and severe h...
12866786 - Effects of psychosocial risk factors and prenatal interventions on birth weight: eviden...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-3-25
Journal Detail:
Title:  Neuroscience letters     Volume:  -     ISSN:  1872-7972     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-3-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011. Published by Elsevier Ireland Ltd.
Affiliation:
Molecular Imaging Center, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Hyperthermia up-regulates matrix metalloproteinases and accelerates basement membrane degradation in...
Next Document:  TEMPORO-PARIETAL JUNCTION IS INVOLVED IN ATTRIBUTION OF HOSTILE INTENTIONALITY IN SOCIAL INTERACTION...