| Determination of Myocardial Viability with ECG-Gated Fluorodeoxyglucose F-18 Positron Emission Tomography. | |
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MedLine Citation:
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PMID: 14516528 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVE: We hypothesize that ECG-gated positron emission tomography (PET) using Fluorodeoxyglucose F-18 (FDG) alone can determine myocardial viability by identifying dysfunctional myocardium with preserved glucose metabolism. We compared the contraction-metabolism pattern of gated FDG PET with the perfusion-metabolism pattern of conventional PET using N-13 ammonia (NH(3)) as a perfusion agent and FDG as a glucose metabolism agent in 21 consecutive patients with chronic coronary artery disease with left ventricular dysfunction (mean ejection fraction 23.6 +/- 7.7%).METHODS: The left ventricle was divided into 17 segments. Uptakes of NH(3) and FDG were scored from absent (0) to normal (4), and wall motion was scored from dyskinesia (-1) to normal (3). Scores were determined by the visual interpretation of the majority of 3 blinded expert readers. Viable myocardium was defined by normal or mildly reduced uptakes of both NH(3) and FDG, perfusion-metabolism mismatch on NH(3)-FDG PET, or normal to mildly reduced uptake of FDG with regional dysfunction on gated FDG PET.RESULTS: Gated FDG PET identified 184 segments as viable, all of which were determined as viable by NH(3)-FDG PET. Among 125 segments identified as nonviable by NH(3)-FDG PET, 76 segments were determined as nonviable by NH(3)-FDG PET. The results provided a positive and negative predictive value of gated FDG PET for the determination of myocardial viability to be 100% and 60.8%, respectively.CONCLUSIONS: Gated FDG PET has a high positive predictive value (100%) for the identification of viable myocardium. |
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Authors:
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Hee Seung Bom; John P. Vansant; Roderic I. Pettigrew; C David Cooke; John R. Votaw; Ernest V. Garcia |
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Publication Detail:
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Type: JOURNAL ARTICLE |
Journal Detail:
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Title: Clinical positron imaging : official journal of the Institute for Clinical P.E.T Volume: 2 ISSN: - ISO Abbreviation: Clin. Positron Imaging Publication Date: 1999 Jul |
Date Detail:
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Created Date: 2003-Sep-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9810966 Medline TA: Clin Positron Imaging Country: - |
Other Details:
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Languages: ENG Pagination: 183-190 Citation Subset: - |
Affiliation:
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Emory Center for Positron Emission Tomography, Atlanta, GA, USA |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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