Document Detail


Determination Method of Clomeprop and Clomeprop Acid in Livestock and Seafood Products by LC-MS/MS.
MedLine Citation:
PMID:  23154761     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
A method using liquid chromatography with tandem mass spectrometry has been developed for the determination of clomeprop and its metabolite clomeprop acid in livestock and seafood products. Clomeprop and clomeprop acid were extracted with acetone-n-hexane mixture under acidic conditions, and were defatted by liquid-liquid separation using acetonitrile and n-hexane, followed cleanup with SAX and PSA cartridges. The average recoveries from 10 kinds of food (bovine muscle, bovine fat, bovine liver, milk, yellowtail, salmon, eel, fresh water clam, egg and honey) spiked at the level of the MRLs or at uniform limits (0.01 ppm) were in the range of 81-97% for clomeprop and 93-101% for clomeprop acid. Repeatability was in the range of 2.1-14% for clomeprop and 1.3-4.0% for clomeprop acid. The quantitation limits were 0.002 mg/kg for clomeprop and 0.00154 mg/kg (0.002 mg/kg as clomeprop) for clomeprop acid.
Authors:
Rie Ishii; Kunihiko Takahashi; Kazuo Toya; Satoru Nemoto; Rieko Matsuda
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan     Volume:  53     ISSN:  1882-1006     ISO Abbreviation:  Shokuhin Eiseigaku Zasshi     Publication Date:  2012  
Date Detail:
Created Date:  2012-11-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0142214     Medline TA:  Shokuhin Eiseigaku Zasshi     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  217-24     Citation Subset:  IM    
Affiliation:
Saitama Prefectural Institute of Public Health.
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