| Determination of Internal Target Volume from a Single Positron Emission Tomography/Computed Tomography Scan in Lung Cancer. | |
| | |
MedLine Citation:
|
PMID: 22197228 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
PURPOSE: The use of four-dimensional computed tomography (4D-CT) to determine the tumor internal target volume (ITV) is usually characterized by high patient radiation exposure. The objective of this study was to propose and evaluate an approach that relies on a single static positron emission tomography (PET)/CT scan to determine the ITV, thereby eliminating the need for 4D-CT and thus reduce patient radiation dose. METHODS AND MATERIALS: The proposed approach is based on the concept that the observed PET image is the result of a joint convolution of an ideal PET image (free from motion and partial volume effect) with a motion-blurring kernel (MBK) and partial volume effect. In this regard, the MBK and tumor ITV are then estimated from the deconvolution of this joint model. To test this technique, phantom and patient studies were performed using different sphere/tumor sizes and motion trajectories. In all studies, a 4D-CT and a PET/CT image of the sphere/tumor were acquired. The ITV from the proposed technique was then compared to the maximum intensity projection (MIP) volume of the 4D-CT images. A Dice coefficient of the two volumes was calculated to represent the similarity between the two ITVs. RESULTS: The average ITVs of the proposed technique were 97.2% ± 0.3% and 81.0% ± 16.7% similar to the MIP volume in the phantom and patient studies, respectively. The average dice coefficients were 0.87 ± 0.05 and 0.73 ± 0.16, respectively, for the two studies. CONCLUSION: Using the proposed approach, a single static PET/CT scan has the potential to replace a 4D-CT to determine the tumor ITV. This approach has the added advantage of reducing patient radiation exposure and determining the tumor MBK compared to 4D-CT/MIP-CT. |
| | |
Authors:
|
Guoping Chang; Tingting Chang; Tinsu Pan; John W Clark; Osama R Mawlawi |
Related Documents
:
|
3014598 - Hepatic lobar atrophy following obstruction of the ipsilateral portal vein from hilar c... 2657118 - The limitations of impedance plethysmography in the diagnosis of acute deep venous thro... 2129848 - Hepatic encephalopathy due to a large intrahepatic communication between the portal vei... 4084928 - Computed tomographic evaluation of compression of the superior vena cava and its tribut... 2426668 - Paradoxical induction of endless loop tachycardia by magnet application over a ddd pace... 20061038 - Cardiac sarcoidosis evaluated by multimodality imaging. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-12-22 |
Journal Detail:
|
Title: International journal of radiation oncology, biology, physics Volume: - ISSN: 1879-355X ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
|
Created Date: 2011-12-26 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7603616 Medline TA: Int J Radiat Oncol Biol Phys Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
|
Department of Electrical and Computer Engineering, Rice University, Houston, Texas. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Impact of Screening and Risk Factors for Local Recurrence and Survival After Conservative Surgery an...
Next Document: Monitoring Dosimetric Impact of Weight Loss with Kilovoltage (KV) Cone Beam CT (CBCT) during Parotid...