| Determination of glomerular filtration rate using dynamic CT-angiography: simultaneous acquisition of morphological and functional information. | |
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MedLine Citation:
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PMID: 20479647 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To determine the feasibility of a dynamic CT angiography-protocol in regard to simultaneous assessment of morphology and function. METHOD AND MATERIALS: Fourteen patients with renal graft dysfunction received a dynamic computed tomography angiography (CTA) using a 128-slice CT-scanner with continuous bi-directional table movement, allowing to cover a scan range of 18 cm within 1.75 seconds. Twelve scans of the entire kidney were acquired every 3.5 seconds with the aim to simultaneously obtain CTA and renal function data. The glomerular filtration rate (GFR) was calculated by a modified Patlak method and compared with creatinine-based formulas (MDRD 4 and endogenous creatinine clearance), that served as reference standard. RESULTS: GFR obtained from dynamic CTA correlates well with the GFR derived by creatinine-based formulas with a correlation coefficient of r = 0.8986; P < 0.0001. The average absolute deviation was 8.1 mL/min. The mean amount of contrast medium required was 35 mL. The average effective dose was 13.8 mSv. CONCLUSION: Dynamic CTA offers the possibility to determine the GFR and thus facilitates simultaneous assessment of morphology and function. Additionally, our dynamic CTA-protocol helps to significantly reduce the amount of contrast medium, which is beneficial for patients with impaired renal function. |
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Authors:
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Andreas Helck; Wieland H Sommer; Ernst Klotz; Matthias Wessely; Steven Pieter Sourbron; Konstantin Nikolaou; Dirk A Clevert; Mike Notohamiprodjo; Wolf D Illner; Maximilian Reiser; Hans-Christoph Becker |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Investigative radiology Volume: 45 ISSN: 1536-0210 ISO Abbreviation: Invest Radiol Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-06-22 Completed Date: 2010-10-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0045377 Medline TA: Invest Radiol Country: United States |
Other Details:
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Languages: eng Pagination: 387-92 Citation Subset: IM |
Affiliation:
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Department of Clinical Radiology, University Hospitals Grosshadern, Ludwig-Maximilians-University of Munich, Munich, Germany. andreas.helck@med.unimuenchen.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Algorithms Angiography / methods* Female Glomerular Filtration Rate* Humans Male Middle Aged Radiographic Image Enhancement / methods* Radiographic Image Interpretation, Computer-Assisted / methods* Renal Artery Obstruction / physiopathology*, radiography* Reproducibility of Results Sensitivity and Specificity Tomography, X-Ray Computed / methods* Young Adult |
| Comments/Corrections | |
Erratum In:
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Invest Radiol. 2010 Aug;45(8):506 Note: Sourbron, Steven Pieter [added] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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