Document Detail


Determination of Epinephrine in Pharmaceutical Formulation by an Optimized Novel Luminescence Method Using CdS Quantum Dots as Sensitizer.
MedLine Citation:
PMID:  23054304     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
In this article, a novel chemiluminescence method using water-soluble CdS quantum dots (QDs) as sensitizers is proposed for the chemiluminometric determination of epinephrine. The method is based on the quenching effect of epinephrine on the chemiluminescence emission generated by the mixing of CdS quantum dots (QDs) with hydrogen carbonate (HCO(3) (-)) in the presence of hydrogen peroxide (H(2)O(2)) in an alkaline medium. The optimization of variables influencing the chemiluminescence response of the method has been carried out by using experimental design. Under the optimal conditions, there is good linear relationship between the relative chemiluminescence intensity and the concentration of epinephrine over the range of 5 × 10(-9)-1 × 10(-6) molL(-1) with a 3σ detection limit of 5 × 10(-11) molL(-1). The method has been successfully applied to the determination of epinephrine in pharmaceutical formulation and the recovery test was done in human urine.
Authors:
Seyed Naser Azizi; Mohammad Javad Chaichi; Parmis Shakeri; Ahmadreza Bekhradnia
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-11
Journal Detail:
Title:  Journal of fluorescence     Volume:  -     ISSN:  1573-4994     ISO Abbreviation:  J Fluoresc     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9201341     Medline TA:  J Fluoresc     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Analytical Division, Faculty of Chemistry, University of Mazandaran, Babolsar, 4741695447, Iran.
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