| Determination of Diabetic Retinopathy Prevalence and Associated Risk Factors in Chinese Diabetic and Pre-diabetic Subjects: Shanghai Diabetic Complications Study. | |
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MedLine Citation:
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PMID: 22139892 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: The prevalence of diabetic retinopathy is not well-studied in the Chinese pre-diabetic population, also known as impaired glucose regulation. Hence, we investigated the prevalence of and risk factors associated with retinopathy in diabetic and pre-diabetic subjects from Chinese communities. METHODS: A total of 3736 Chinese subjects were recruited from urban communities in Shanghai. The participants were classified as normal glucose tolerance (NGT), impaired glucose regulation (IGR) and diabetes based on the 75 g oral glucose tolerance test. The levels of diabetic retinopathy (DR) were assessed with non-mydriatic retinal photographs according to the Diabetic Retinopathy Disease Severity Scale. RESULTS: The prevalence of DR in diabetes and IGR subjects was 9.4% and 2.5%, respectively. In subjects with IGR, hypertension (odds ratio: 3.54, P = 0.028), including elevated systolic and diastolic blood pressure, and obesity (odds ratio: 3.53, P = 0.028) were significantly associated with DR after age and sex adjustments. The factors associated with retinopathy in diabetes included diabetes duration, blood glucose levels, glycated hemoglobin levels, and the presence of albuminuria. DR was significantly associated with fasting plasma glucose in known diabetes; while in newly-diagnosed subjects, DR was closely correlated to postprandial plasma glucose. CONCLUSIONS: Hyperglycemia was a strong risk factor for DR. In pre-diabetic subjects, diabetic retinopathy was associated with hypertension and obesity. Copyright © 2002 John Wiley & Sons, Ltd. |
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Authors:
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Can Pang; Lili Jia; Sunfang Jiang; Wei Liu; Xuhong Hou; Yuhua Zuo; Huilin Gu; Yuqian Bao; Qiang Wu; Kunsan Xiang; Xin Gao; Weiping Jia |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-5 |
Journal Detail:
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Title: Diabetes/metabolism research and reviews Volume: - ISSN: 1520-7560 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-5 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100883450 Medline TA: Diabetes Metab Res Rev Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2002 John Wiley & Sons, Ltd. |
Affiliation:
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Department of Endocrinology and Metabolism, Shanghai Jiaotong University Affiliated Sixth People's Hospital; Shanghai Clinical Center for Diabetes; Shanghai Key Laboratory of Diabetes Mellitus; Shanghai Diabetes Institute, Shanghai, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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