Document Detail

Determination of 4-O-methylated catecholamine metabolites in urine by mass fragmentography.
MedLine Citation:
PMID:  476919     Owner:  NLM     Status:  MEDLINE    
We describe the determination of the 4-O-methylated catecholamine metabolites 4-methoxy-3-hydroxyphenylacetic acid (iso-HVA), 4-methoxy-3-hydroxyphenylmandelic acid (iso-VMA) and 4-methoxy-3-hydroxyphenylethylene glycol (iso-MOPEG) in urine with use of mass fragmentography and deuterated internal standards. Normal values, expressed in terms of creatinine, are given as a function of age. Urinary excretion values during neuroblastoma, pheochromocytoma, and parkinsonism treated with L-DOPA, and during the intravenous administration of dopamine are discussed. For normal persons, the mean percentages (+/- SD) of 4-O-methylated metabolites relative to their 3-O-methylated analogs were 6.29 +/- 2.79% (iso-HVA/HVA), 0.70 +/- 0.57% (iso-VMA/VMA), and 0.77 +/- 0.53% (iso-MOPEG/MOPEG). We observed no significant changes in these parameters for the patients studied and conclude that the determination of 4-O-methylated catecholamine metabolites for these patients does not add information to the results obtained from their quantitatively more important 3-O-methylated analogs.
F A Muskiet; D C Fremouw-Ottevangers; G T Nagel; B G Wolthers
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical chemistry     Volume:  25     ISSN:  0009-9147     ISO Abbreviation:  Clin. Chem.     Publication Date:  1979 Oct 
Date Detail:
Created Date:  1979-11-29     Completed Date:  1979-11-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9421549     Medline TA:  Clin Chem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1708-13     Citation Subset:  IM    
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MeSH Terms
Gas Chromatography-Mass Spectrometry / methods
Glycols / urine*
Homovanillic Acid / analogs & derivatives,  urine*
Methoxyhydroxyphenylglycol / analogs & derivatives,  urine*
Phenylacetates / urine*
Structure-Activity Relationship
Vanilmandelic Acid / analogs & derivatives,  urine*
Reg. No./Substance:
0/Glycols; 0/Phenylacetates; 306-08-1/Homovanillic Acid; 534-82-7/Methoxyhydroxyphenylglycol; 55-10-7/Vanilmandelic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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