Document Detail

Determination of 2,6-diisopropylnaphthalene (DIPN) and n-dibutylphthalate (DBP) in food and paper packaging materials from US marketplaces.
MedLine Citation:
PMID:  19680850     Owner:  NLM     Status:  MEDLINE    
A gas chromatography-ion-trap tandem mass spectrometry procedure was developed for the determination of 2,6-diisopropylnaphthalene (DIPN) and n-dibutylphthalate (DBP) in domestic and imported paper packages and food sold in US marketplaces. The procedure involved ultrasonic extraction with dichloromethane, followed by analysis with the gas chromatography-ion-trap tandem mass spectrometry. Calibration curves for DIPN and DBP were achieved with concentrations ranging from 0.01 to 10 microg ml(-1) and the corresponding r(2) values were 0.9976 and 0.9956, respectively. In most of the fortified samples the recoveries were higher than 80% with a relative standard deviation (RSD) <10%. Using this procedure, it was found that less than 20% of the tested domestic packages and more than 60% of the tested imported food packages contained both DIPN and DBP. The concentrations of DIPN and DBP ranged from 0.09 to 20 mg kg(-1) and 0.14 to 55 mg kg(-1), respectively, with most of the DINP and DBP levels lower than 20 mg kg(-1). DIPN was not detected (<0.01 mg kg(-1)) in 41 food samples and DBP was only detected in two domestic and four imported food samples with concentrations ranging from <0.01 to 0.81 mg kg(-1).
K Zhang; G O Noonan; T H Begley
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment     Volume:  25     ISSN:  1944-0057     ISO Abbreviation:  Food Addit Contam Part A Chem Anal Control Expo Risk Assess     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2009-08-14     Completed Date:  2010-01-21     Revised Date:  2013-01-28    
Medline Journal Info:
Nlm Unique ID:  101485040     Medline TA:  Food Addit Contam Part A Chem Anal Control Expo Risk Assess     Country:  England    
Other Details:
Languages:  eng     Pagination:  1416-23     Citation Subset:  IM    
US Food and Drug Administration, Centre for Food Safety & Applied Nutrition (CFSAN), MD, USA.
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MeSH Terms
Dibutyl Phthalate / analysis*
Food Analysis / methods
Food Contamination / analysis*
Food Packaging*
Gas Chromatography-Mass Spectrometry / methods
Naphthalenes / analysis*
Plasticizers / analysis*
Tandem Mass Spectrometry / methods
United States
Reg. No./Substance:
0/Naphthalenes; 0/Plasticizers; 1X71YEU9QB/2,6-diisopropylnaphthalene; 84-74-2/Dibutyl Phthalate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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