Document Detail

Determinants of total and specific IgE in infants with atopic dermatitis. ETAC Study Group. Early Treatment of the Atopic Child.
MedLine Citation:
PMID:  9553982     Owner:  NLM     Status:  MEDLINE    
ETAC (Early Treatment of the Atopic Child), a multi-centre predominantly European study to investigate the potential for cetirizine to prevent the development of asthma in infants with atopic dermatitis has completed enrollment: 817 children have been randomised to 18 months' treatment with either active or placebo and a subsequent 18 months of post-treatment follow-up. Results of the therapeutic effects will not be available for some time, but the study has provided an opportunity to investigate influences on sensitization to allergens in a large cohort of 1-2 years olds with already established atopic dermatitis, resident in different countries and in different environments. The study shows that in infants with atopic dermatitis, raised serum total IgE has significantly different determinants from that a specific allergen sensitization. In infancy, increased total IgE is more affected by factors increasing risk of intercurrent infection and non-specific airway inflammation, such as environmental tobacco smoke exposure (p < 0.001) and the use of gas cookers (p = 0.02). Specific allergen sensitization as represented by detectable IgE antibodies is influenced primarily by allergen exposure. In Sweden, low level exposure to allergens is associated with reduced specific allergen sensitization rates even though the infants already have atopic dermatitis.
Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial    
Journal Detail:
Title:  Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology     Volume:  8     ISSN:  0905-6157     ISO Abbreviation:  Pediatr Allergy Immunol     Publication Date:  1997 Nov 
Date Detail:
Created Date:  1998-06-04     Completed Date:  1998-06-04     Revised Date:  2008-05-28    
Medline Journal Info:
Nlm Unique ID:  9106718     Medline TA:  Pediatr Allergy Immunol     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  177-84     Citation Subset:  IM    
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MeSH Terms
Allergens / immunology
Anti-Allergic Agents / therapeutic use
Antibody Specificity / immunology*
Biological Markers / blood
Cetirizine / therapeutic use
Child, Preschool
Dermatitis, Atopic / drug therapy,  immunology*
Immunoglobulin E / blood*,  immunology
Milk / immunology
Mites / immunology
Observer Variation
Reg. No./Substance:
0/Allergens; 0/Anti-Allergic Agents; 0/Biological Markers; 37341-29-0/Immunoglobulin E; 83881-51-0/Cetirizine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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