Document Detail

Determinants of sudden cardiac death in patients with persistent atrial fibrillation in the rate control versus electrical cardioversion (RACE) study.
MedLine Citation:
PMID:  16996876     Owner:  NLM     Status:  MEDLINE    
This report evaluated the correlates of sudden cardiac and nonsudden cardiac death in patients with persistent atrial fibrillation randomized to rate or rhythm control in the RAte Control vs Electrical cardioversion (RACE) study. Sudden cardiac death was observed in 16 patients, 8 patients in each group. Previous myocardial infarction resulted in a 4.9-fold increased risk of sudden death (95% confidence interval 1.8 to 13.2). The use of beta blockers showed their protective nature (hazard ratio 0.2, 95% confidence interval 0.05 to 0.9). The randomized treatment strategy, heart rhythm during follow-up, use of antiarrhythmic drugs, and number of stroke risk factors were not associated with sudden cardiac death. In conclusion, the treatment of underlying disease, rather than the heart rhythm, seems essential to prevent mortality.
Vincent E Hagens; Michiel Rienstra; Dirk J Van Veldhuisen; Harry J G M Crijns; Isabelle C Van Gelder
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2006-08-11
Journal Detail:
Title:  The American journal of cardiology     Volume:  98     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-09-25     Completed Date:  2006-11-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  929-32     Citation Subset:  AIM; IM    
Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
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MeSH Terms
Adrenergic beta-Antagonists / therapeutic use
Amiodarone / therapeutic use
Anti-Arrhythmia Agents / therapeutic use*
Atrial Fibrillation / mortality,  therapy*
Calcium Channel Blockers / therapeutic use
Death, Sudden, Cardiac*
Diabetes Mellitus / epidemiology
Digitalis Glycosides / therapeutic use
Electric Countershock*
Fatigue / epidemiology
Flecainide / therapeutic use
Follow-Up Studies
Myocardial Infarction / epidemiology
Netherlands / epidemiology
Proportional Hazards Models
Recurrence / prevention & control
Risk Factors
Sotalol / therapeutic use
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Anti-Arrhythmia Agents; 0/Calcium Channel Blockers; 0/Digitalis Glycosides; 1951-25-3/Amiodarone; 3930-20-9/Sotalol; 54143-55-4/Flecainide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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