| Determinants of success in national programs to eliminate lymphatic filariasis: a perspective identifying essential elements and research needs. | |
| | |
MedLine Citation:
|
PMID: 18840733 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The Global Programme to Eliminate Lymphatic Filariasis (GPELF) was launched in 2000. To understand why some national programs have been more successful than others, a panel of individuals with expertise in LF elimination efforts met to assess available data from programs in 8 countries. The goal was to identify: 1) the factors determining success for national LF elimination programs (defined as the rapid, sustained reduction in microfilaremia/antigenemia after repeated mass drug administration [MDA]); 2) the priorities for operational research to enhance LF elimination efforts. Of more than 40 factors identified, the most prominent were 1) initial level of LF endemicity; 2) effectiveness of vector mosquitoes; 3) MDA drug regimen; 4) population compliance. Research important for facilitating program success was identified as either biologic (i.e., [1] quantifying differences in vectorial capacity; [2] identifying seasonal variations affecting LF transmission) or programmatic (i.e., [1] identifying quantitative thresholds, especially the population compliance levels necessary for success, and the antigenemia or microfilaremia prevalence at which MDA programs can stop with minimal risk of resumption of transmission; [2] defining optimal drug distribution strategies and timing; [3] identifying those individuals who are "persistently non-compliant" during MDAs, the reasons for this non-compliance and approaches to overcoming it). While addressing these challenges is important, many key determinants of program success are already clearly understood; operationalizing these as soon as possible will greatly increase the potential for national program success. |
| | |
Authors:
|
Dominique Kyelem; Gautam Biswas; Moses J Bockarie; Mark H Bradley; Maged El-Setouhy; Peter U Fischer; Ralph H Henderson; James W Kazura; Patrick J Lammie; Sammy M Njenga; Eric A Ottesen; Kapa D Ramaiah; Frank O Richards; Gary J Weil; Steven A Williams |
Related Documents
:
|
6925093 - Teen advocate program. 16687703 - Hivcorps: using volunteers to rapidly expand hiv health services across zambia. 15271043 - Evaluating the impact of moving from discipline-based to integrated assessment. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: The American journal of tropical medicine and hygiene Volume: 79 ISSN: 1476-1645 ISO Abbreviation: Am. J. Trop. Med. Hyg. Publication Date: 2008 Oct |
Date Detail:
|
Created Date: 2008-10-08 Completed Date: 2008-10-21 Revised Date: 2011-11-08 |
Medline Journal Info:
|
Nlm Unique ID: 0370507 Medline TA: Am J Trop Med Hyg Country: United States |
Other Details:
|
Languages: eng Pagination: 480-4 Citation Subset: AIM; IM |
Affiliation:
|
Lymphatic Filariasis Support Center, Task Force for Child Survival and Development, Decatur, Georgia 30030, USA. dkyelem@taskforce.org |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Elephantiasis, Filarial
/
drug therapy,
epidemiology,
prevention & control* Humans Program Evaluation Research |
| Grant Support | |
ID/Acronym/Agency:
|
U19 AI065717-04/AI/NIAID NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Dracunculiasis eradication: neglected no longer.
Next Document: Risk factors for dengue virus infection in rural Amazonia: population-based cross-sectional surveys.