Document Detail

Determinants of sodium removal with tidal automated peritoneal dialysis.
MedLine Citation:
PMID:  23311207     Owner:  NLM     Status:  In-Process    
In a comprehensive evaluation of dialysis adequacy, major attention has been recently paid to fluid and Na balance. Removal of Na has been reported to be significantly poorer with automated peritoneal dialysis (APD) than with continuous ambulatory peritoneal dialysis. Only limited data on Na removal with tidal APD have been published. We analyzed peritoneal Na mass balance in 122 separate nightly tidal APD sessions performed by 7 peritonitis-free, clinically stable, patients with negligible residual renal function (< 100 mL urine daily). Correlations with other efficiency measures [ultrafiltration (UF) and small-solute clearances], prescriptive parameters [duration of treatment, initial intraperitoneal fill volume (IPV) and its tidal percentage, and dialysate flux] and peritoneal transport status were tested in univariate and multivariate linear regression models. Removal of Na was 89 +/- 55 mmol per treatment, which correlated with UF (r = 0.29, p = 0.001) and was higher in patients with high-average transport (118 +/- 41 mmol vs. 81 +/- 56 mmol in low-average transporters, p = 0.0004), in whom a significant positive correlation was found with initial IPV and duration of treatment (r = 0.55; 95% confidence interval: 0.21 to 0.77; p = 0.0029; and r = 0.66; 95% confidence interval: 0.38 to 0.83; p = 0.0002 respectively). Removal of Na correlated weakly with UF in tidal APD and showed wide inter-patient variability. It should therefore be measured rather than roughly estimated from UF. Its magnitude exposes the anuric patient on nightly APD with a "dry" day to the risk of Na retention, unless controlled Na intake or dialytic strategies aimed at enhancing Na removal, or both, are implemented.
Alessandro Domenici; Luca Scabbia; Francesca Sivo; Clorinda Falcone; Giorgio Punzo; Paolo Menè
Related Documents :
1953317 - Upper extremity contractures in a patient with eosinophilia-myalgia syndrome.
2121457 - Total parenteral nutrition 1990. a review of its current status in hospitalised patient...
3833527 - Responses to epinephrine in patients with anorexia nervosa.
23737517 - Impact of severe hypothyroidism on cyclophosphamide disposition and routes of metabolis...
15089017 - Writing about patients: ii. patients' reading about themselves and their analysts' perc...
300027 - Hla antigens and antinuclear antibody titres in juvenile chronic iridocyclitis.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Advances in peritoneal dialysis. Conference on Peritoneal Dialysis     Volume:  28     ISSN:  1197-8554     ISO Abbreviation:  Adv Perit Dial     Publication Date:  2012  
Date Detail:
Created Date:  2013-01-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9104803     Medline TA:  Adv Perit Dial     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  16-20     Citation Subset:  IM    
Department of Nephrology, Sapienza University, Sant'Andrea Hospital, Rome, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Salt intake and hypervolemia in the development of hypertension in peritoneal dialysis patients.
Next Document:  Influence of prednisolone on glucose and uric acid transport across peritoneal membrane in vitro.