Document Detail

Determinants of the severity of exercise-induced bronchoconstriction in patients with asthma.
MedLine Citation:
PMID:  15260459     Owner:  NLM     Status:  MEDLINE    
AIM: In examining the mechanisms of exercise-induced bronchoconstriction (EIB), it is important to determine which factors most strongly affect the severity of EIB. We determined such factors in patients with asthma by stepwise multiple-regression analysis. METHODS: Twenty-three patients with asthma underwent pulmonary function tests, methacholine provocation test, and sputum induction. Eosinophilic inflammatory indices and airway vascular permeability index (ratio of albumin concentrations in induced sputum and serum) were examined in sputum samples, and then an exercise test was performed by all asthmatics. RESULTS: There was a significant correlation between the severity of EIB and degree of eosinophilic inflammation in induced sputum. Moreover, there was a significant correlation between the severity of EIB and airway vascular permeability index. Although we could not find a significant correlation between the severity of EIB and 1-sec forced expired volume, 20% provocation concentration of (PC20) methacholine tended to be correlated with the severity of EIB. By stepwise multiple-regression analysis, we also found that airway vascular permeability index, eosinophil cationic protein levels in sputum, and PC20 methacholine are independent predictors of the severity of EIB. CONCLUSION: We found that airway vascular hyperpermeability, eosinophilic inflammation, and bronchial hyperreactivity are independent factors predicting the severity of EIB.
Kenichiro Otani; Hiroshi Kanazawa; Hiroshi Fujiwara; Kazuto Hirata; Shigeo Fujimoto; Junichi Yoshikawa
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of asthma : official journal of the Association for the Care of Asthma     Volume:  41     ISSN:  0277-0903     ISO Abbreviation:  J Asthma     Publication Date:  2004  
Date Detail:
Created Date:  2004-07-20     Completed Date:  2004-08-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8106454     Medline TA:  J Asthma     Country:  United States    
Other Details:
Languages:  eng     Pagination:  271-8     Citation Subset:  IM    
Department of Respiratory Medicine, Graduate School of Medicine, Osaka City University, Osaka, Japan.
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MeSH Terms
Asthma / immunology,  physiopathology
Asthma, Exercise-Induced / immunology*,  physiopathology*
Bronchi / physiopathology
Capillary Permeability / physiology*
Eosinophils / immunology*
Respiratory Function Tests
Risk Factors
Severity of Illness Index

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