Document Detail


Determinants of risk factors of atherosclerosis in the postinfarction period: the Tallinn MI study.
MedLine Citation:
PMID:  16714248     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Environmental as well as genetic factors are involved in the pathogenesis of myocardial infarction. The disease is a frequent cause of mortality in the middle-aged male population of Estonia. The high prevalence of premature myocardial infarction (PMI) in this country is not fully understood. The association of atherogenic and thrombogenetic risk factors with lifestyle was evaluated in men who had suffered myocardial infarction at 55 years of age (n = 71) and in randomly selected corresponding controls (n = 85). Serum routine lipids, apolipoprotein (apo)A-I, apoB, apoE polymorphism, lipoprotein(a) and fibrinogen levels were determined. Behavioural risk factors, indices of obesity, blood pressure and pedigree data were registered. In 80.6 % of PMI subjects some type of hyperlipidaemia was observed (European Atherosclerosis Society Classification) and lipid-lowering drugs were taken by 13.9 % of patients. In PMI patients the most common positive determinants of atherogenic lipoprotein indices were waist-to-hip ratio and physical inactivity, and in controls, waist-to-hip ratio and apoE phenotype. The odds ratio (OR) of PMI was 8.9-fold greater in the highest tertile of apoB/apoA-I distribution compared with the lowest tertile. The OR of PMI in the highest tertile of fibrinogen distribution versus the lowest tertile was 6.2 (95 % CI 2.46-15.44), and OR of PMI in the highest Lp(a) tertile versus the lowest was 3.1 (95 % CI 1.31-7.40). Thus, atherogenic dyslipidaemia was the most serious cardiovascular risk factor among PMI patients. From two thrombogenesis-related markers, the levels of fibrinogen and Lp(a), the first one was more strongly associated with PMI status.
Authors:
K Aasvee; M Jauhiainen; E Kurvinen; I Tur; J Sundvall; T Roovere; A Baburin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Scandinavian journal of clinical and laboratory investigation     Volume:  66     ISSN:  0036-5513     ISO Abbreviation:  Scand. J. Clin. Lab. Invest.     Publication Date:  2006  
Date Detail:
Created Date:  2006-05-22     Completed Date:  2006-07-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0404375     Medline TA:  Scand J Clin Lab Invest     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  191-9     Citation Subset:  IM    
Affiliation:
Department of Molecular Medicine, National Public Health Institute, Biomedicum, Helsinki, Finland. katrin.aasvee@tai.ee
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MeSH Terms
Descriptor/Qualifier:
Alleles
Apolipoprotein E4
Apolipoproteins E / genetics
Atherosclerosis / blood,  etiology*,  pathology
Case-Control Studies
Estonia
Exercise
Humans
Hyperlipidemias / complications
Linear Models
Lipids / blood
Logistic Models
Middle Aged
Myocardial Infarction / complications*
Risk Factors
Risk-Taking
Waist-Hip Ratio
Chemical
Reg. No./Substance:
0/Apolipoprotein E4; 0/Apolipoproteins E; 0/Lipids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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