Document Detail

Determinants of right ventricular muscle mass in idiopathic dilated cardiomyopathy: impact of left ventricular muscle mass and pulmonary hypertension.
MedLine Citation:
PMID:  24936147     Owner:  NLM     Status:  In-Data-Review    
INTRODUCTION: Although chronic pulmonary hypertension and right ventricular (RV) function carry important functional and prognostic implications in idiopathic dilated cardiomyopathy (IDC), little information on RV muscle mass (RVMM) and its determinants has been published.
METHODS: Our study comprised thirty-five consecutive patients with IDC, left ventricular (LV) ejection fraction <40% and NYHA class ≥2. Hemodynamic data and parameters on LV and RV geometry were derived from right heart catheterisation and cardiac magnetic resonance imaging.
RESULTS: RVMM was normalized to body size using a common linear, body surface area based approach (RVMMI) and by an allometric index (RVMM-AI) incorporating adjustment for age, height and weight. Stepwise multiple regression analysis revealed that pulmonary artery pressure and left ventricular muscle mass were independent predictors of RVMM-AI. The interventricular mass ratio of RV and LV mass (IVRM) was closely related to RVMM (r = 0.79, p < 0.001) and total muscle mass (r = 0.39, p < 0.02). However, there was no significant relationship between LVMM and IVMR (r = 0.17, p = 0.32).
CONCLUSION: Our data suggest that an increase in RV mass in IDC may be explained by two mechanisms: First, as a consequence of the myopathic process itself resulting in a balanced hypertrophy of both ventricles. Second, due to the chamber specific burden of pulmonary artery pressure rise, resulting in unbalanced RV hypertrophy.
Julia Vormbrock; Jeanette Liebeton; Sophia Wirdeier; Axel Meissner; Thomas Butz; Hans-Joachim Trappe; Gunnar Plehn
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Publication Detail:
Type:  Journal Article     Date:  2014-06-07
Journal Detail:
Title:  International journal of medical sciences     Volume:  11     ISSN:  1449-1907     ISO Abbreviation:  Int J Med Sci     Publication Date:  2014  
Date Detail:
Created Date:  2014-06-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101213954     Medline TA:  Int J Med Sci     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  834-40     Citation Subset:  IM    
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