Document Detail


Determinants of retinal microvascular architecture in normal subjects.
MedLine Citation:
PMID:  19206002     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Recent studies have shown that changes in the retinal microvasculature predict cardiovascular disease (CVD); however, little is known regarding influences on the retinal microvasculature in healthy people without overt cardiovascular or metabolic disease.
METHODS: We used a semiautomated computerized technique to analyze digitized retinal photographs from a total of 167 healthy people (age range, 45-75 years; 83 female), without clinical CVD, diabetes, or hypertension, randomly sampled from the population-based Beaver Dam Eye Study. We assessed arteriolar and venular narrowing, arteriolar optimality deviation, and other quantitative aspects of the retinal microvasculature.
RESULTS: Arterioles were significantly narrower and longer, had wider branching angles, and were more tortuous than venules. Increased arteriolar length to diameter ratio (an index of ratio arteriolar narrowing) was positively and independently associated with older age and elevated systolic blood pressure. Arteriolar optimality deviation (an index of microvascular endothelial dysfunction) increased with greater body mass index. Current smoking and increased white blood cell (WBC) count was associated with wider venules. After controlling for smoking, WBC was no longer a significant predictor of venular diameter.
CONCLUSIONS: CVD risk factors are associated with retinal microvascular changes in healthy individuals without evidence of CVD, diabetes, or hypertension. CVD risk factors have different influences on the arteriolar and venular bed.
Authors:
Alun D Hughes; Tien Y Wong; Nicholas Witt; Richard Evans; Simon A Mcg Thom; Barbara E Klein; Nish Chaturvedi; Ronald Klein
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Microcirculation (New York, N.Y. : 1994)     Volume:  16     ISSN:  1549-8719     ISO Abbreviation:  Microcirculation     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-02-11     Completed Date:  2009-04-14     Revised Date:  2010-12-03    
Medline Journal Info:
Nlm Unique ID:  9434935     Medline TA:  Microcirculation     Country:  United States    
Other Details:
Languages:  eng     Pagination:  159-66     Citation Subset:  IM    
Affiliation:
Clinical Pharmacology, NHLI Division, International Centre for Circulatory Health, Faculty of Medicine, Imperial College London, UK. a.hughes@imperial.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Aged
Arterioles / anatomy & histology,  physiology
Blood Pressure / physiology
Cardiovascular Diseases / blood,  pathology,  physiopathology
Female
Humans
Image Processing, Computer-Assisted*
Leukocyte Count
Male
Microcirculation / physiology*
Middle Aged
Retina / anatomy & histology,  physiology*
Retinal Vessels / anatomy & histology,  physiology*
Venules / anatomy & histology,  physiology
Grant Support
ID/Acronym/Agency:
EY06594/EY/NEI NIH HHS; //Wellcome Trust

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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