| Determinants of restenosis and lack of effect of dietary supplementation with eicosapentaenoic acid on the incidence of coronary artery restenosis after angioplasty. | |
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MedLine Citation:
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PMID: 2537349 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of an eicosapentaenoic acid-rich encapsulated preparation of fish oil on the incidence of early restenosis after coronary angioplasty was assessed by a randomized double-blind placebo-controlled study. A total of 108 patients received either 10 capsules of fish oil (1.8 g eicosapentaenoic acid, 1.2 g docosahexaenoic acid) or 10 control capsules (50% olive oil, 50% corn oil), commencing the day before angioplasty and continuing for 4 months after angioplasty, in addition to treatment with aspirin and verapamil. In 101 (94%) of the 108 patients, follow-up angiographic or postmortem result was evaluated at a mean (+/- SD) of 100 (+/- 22) days. Angiographic restenosis was observed in 34% of patients (29% of lesions) in the fish oil-treated group and 33% of patients (31% of lesions) in the control group (no significant difference). The overall incidence of angiographic restenosis was significantly higher in patients with 1) recurrent angina pectoris, 2) a positive exercise test at follow-up after angioplasty, 3) residual stenosis greater than 30% immediately after angioplasty, and 4) dilation of the left anterior descending or right coronary artery. Biochemical investigations showed a greater decrease in the serum triglyceride levels in the fish oil-treated group versus the control group (p less than 0.05) but no differences between the two groups in cholesterol levels or platelet counts over the 4 month period. In conclusion, in this study, the administration of fish oil at a dose of 10 capsules/day did not reduce the incidence of early restenosis after coronary angioplasty. |
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Authors:
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L E Grigg; T W Kay; P A Valentine; R Larkins; D J Flower; E G Manolas; K O'Dea; A J Sinclair; J L Hopper; D Hunt |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of the American College of Cardiology Volume: 13 ISSN: 0735-1097 ISO Abbreviation: J. Am. Coll. Cardiol. Publication Date: 1989 Mar |
Date Detail:
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Created Date: 1989-04-05 Completed Date: 1989-04-05 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8301365 Medline TA: J Am Coll Cardiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 665-72 Citation Subset: AIM; IM |
Affiliation:
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Department of Cardiology, Royal Melbourne Hospital, Victoria, Australia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Angioplasty, Balloon* Arachidonic Acid Arachidonic Acids / blood Cholesterol / blood Coronary Disease / prevention & control*, radiography, therapy Double-Blind Method Eicosapentaenoic Acid / blood, therapeutic use* Female Fish Oils / therapeutic use Follow-Up Studies Humans Male Middle Aged Random Allocation Recurrence Risk Factors |
| Chemical | |
Reg. No./Substance:
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0/Arachidonic Acids; 0/Fish Oils; 1553-41-9/Eicosapentaenoic Acid; 506-32-1/Arachidonic Acid; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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