Document Detail

Determinants of restenosis and lack of effect of dietary supplementation with eicosapentaenoic acid on the incidence of coronary artery restenosis after angioplasty.
MedLine Citation:
PMID:  2537349     Owner:  NLM     Status:  MEDLINE    
The effect of an eicosapentaenoic acid-rich encapsulated preparation of fish oil on the incidence of early restenosis after coronary angioplasty was assessed by a randomized double-blind placebo-controlled study. A total of 108 patients received either 10 capsules of fish oil (1.8 g eicosapentaenoic acid, 1.2 g docosahexaenoic acid) or 10 control capsules (50% olive oil, 50% corn oil), commencing the day before angioplasty and continuing for 4 months after angioplasty, in addition to treatment with aspirin and verapamil. In 101 (94%) of the 108 patients, follow-up angiographic or postmortem result was evaluated at a mean (+/- SD) of 100 (+/- 22) days. Angiographic restenosis was observed in 34% of patients (29% of lesions) in the fish oil-treated group and 33% of patients (31% of lesions) in the control group (no significant difference). The overall incidence of angiographic restenosis was significantly higher in patients with 1) recurrent angina pectoris, 2) a positive exercise test at follow-up after angioplasty, 3) residual stenosis greater than 30% immediately after angioplasty, and 4) dilation of the left anterior descending or right coronary artery. Biochemical investigations showed a greater decrease in the serum triglyceride levels in the fish oil-treated group versus the control group (p less than 0.05) but no differences between the two groups in cholesterol levels or platelet counts over the 4 month period. In conclusion, in this study, the administration of fish oil at a dose of 10 capsules/day did not reduce the incidence of early restenosis after coronary angioplasty.
L E Grigg; T W Kay; P A Valentine; R Larkins; D J Flower; E G Manolas; K O'Dea; A J Sinclair; J L Hopper; D Hunt
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the American College of Cardiology     Volume:  13     ISSN:  0735-1097     ISO Abbreviation:  J. Am. Coll. Cardiol.     Publication Date:  1989 Mar 
Date Detail:
Created Date:  1989-04-05     Completed Date:  1989-04-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8301365     Medline TA:  J Am Coll Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  665-72     Citation Subset:  AIM; IM    
Department of Cardiology, Royal Melbourne Hospital, Victoria, Australia.
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MeSH Terms
Angioplasty, Balloon*
Arachidonic Acid
Arachidonic Acids / blood
Cholesterol / blood
Coronary Disease / prevention & control*,  radiography,  therapy
Double-Blind Method
Eicosapentaenoic Acid / blood,  therapeutic use*
Fish Oils / therapeutic use
Follow-Up Studies
Middle Aged
Random Allocation
Risk Factors
Reg. No./Substance:
0/Arachidonic Acids; 0/Fish Oils; 1553-41-9/Eicosapentaenoic Acid; 506-32-1/Arachidonic Acid; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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