| Determinants of reproductive outcome after abdominal myomectomy for infertility. | |
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MedLine Citation:
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PMID: 10428157 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine the effect of myomectomy as a therapy for infertility and to define the factors that influence reproductive outcome. DESIGN: Retrospective study of a case series. SETTING: An academic department specializing in conservative surgery. PATIENT(S): A total of 138 infertile women who underwent first-line conservative surgical treatment at laparotomy for uterine leiomyomas over an 8-year period. INTERVENTION(S): Data were collected on baseline clinical characteristics, surgical details, and subsequent reproductive history. MAIN OUTCOME MEASURE(S): Cumulative pregnancy rates at 24 months according to selected clinical and fibroid characteristics. RESULT(S): Pregnancy occurred in 76 women. The 24-month cumulative probability of conception according to the Kaplan-Meier method was 87% in patients <30 years of age, 66% in patients 30-35 years of age, and 47% in patients >35 years of age. The pregnancy rates in women with and without minor infertility factors in addition to myomas were 56% and 71%, respectively, and those in women with <2 years versus > or =2 years of infertility were 84% and 51%, respectively. The size and site of the largest myoma and the total number of tumors removed did not influence the outcome. CONCLUSION(S): Our results suggest a benefit of myomectomy in infertile patients. However, women should be counseled carefully before surgery because the determinants of outcome appear to be independent of treatment. |
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Authors:
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P Vercellini; S Maddalena; O De Giorgi; A Pesole; L Ferrari; P G Crosignani |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Fertility and sterility Volume: 72 ISSN: 0015-0282 ISO Abbreviation: Fertil. Steril. Publication Date: 1999 Jul |
Date Detail:
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Created Date: 1999-08-26 Completed Date: 1999-08-26 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0372772 Medline TA: Fertil Steril Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 109-14 Citation Subset: IM |
Affiliation:
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Clinica Ostetrica e Ginecologica Luigi Mangiagalli, University of Milano and Istituti Clinici di Perfezionamento, Italy. pgcros@imiucca.unimi.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Female Follow-Up Studies Humans Infertility / etiology, surgery* Leiomyoma / complications, surgery* Postoperative Period Pregnancy Pregnancy Rate* Recurrence Retrospective Studies Treatment Outcome Uterine Neoplasms / complications, surgery* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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