| Determinants of regional ventilation and blood flow in the lung. | |
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MedLine Citation:
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PMID: 19760203 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The principles of ventilation and perfusion distribution in the lung form the foundation of pulmonary physiology and remain cornerstones in caring for critically ill patients. Due to improved imaging technologies with greater spatial resolution, our understanding of the determinants of local ventilation and blood flow have evolved over the past five decades. This review provides a brief history of how the concepts governing regional ventilation and perfusion have developed and presents the most recent studies that are shaping new perspectives on the determinants of ventilation and perfusion. How these new principles apply to acute lung injury and gas exchange in the intensive care unit(ICU) are reviewed. |
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Authors:
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Robb W Glenny |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Intensive care medicine Volume: 35 ISSN: 1432-1238 ISO Abbreviation: Intensive Care Med Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-10-26 Completed Date: 2010-01-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7704851 Medline TA: Intensive Care Med Country: United States |
Other Details:
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Languages: eng Pagination: 1833-42 Citation Subset: IM |
Affiliation:
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Division of Pulmonary and Critical Care Medicine, Departments of Medicine and of Physiology and Biophysics, University of Washington, Seattle, USA. glenny@u.washington.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Lung Injury
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diagnosis,
physiopathology,
therapy Animals Humans Intensive Care / methods Lung / blood supply*, physiology, radiography, radionuclide imaging Lung Compliance Models, Biological Positron-Emission Tomography Pulmonary Circulation / physiology* Pulmonary Gas Exchange / physiology* Regional Blood Flow / physiology* Respiration, Artificial / adverse effects, methods* Respiratory Mechanics / physiology Tomography, Emission-Computed, Single-Photon Tomography, X-Ray Computed Vascular Resistance / physiology Ventilation-Perfusion Ratio / physiology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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