Document Detail

Determinants of pulmonary hypertension in young adults.
MedLine Citation:
PMID:  22943514     Owner:  NLM     Status:  In-Data-Review    
Background:  Risk factors of pulmonary hypertension (PH) are poorly understood. The objective of this study was to identify the determinants of PH in young adults. Methods:  We analysed a limited access dataset from the CARDIA (Coronary Artery Risk Development in Young Adults) study provided by the National Heart, Lung and Blood Institute. Pulmonary arterial pressure was assessed by the Doppler pulmonary artery acceleration time (PAAT). Socio-demographic characteristics, self-reported clinical variables, echocardiographic variables, pulmonary function tests, systemic blood pressure and body mass index calculated from height and weight were used in multivariate analysis. Results:  There were 4171 study subjects, mean age 24.9 ± 3.6 years, retained in year five with echocardiographic data available after five years of follow-up. The prevalence of severe PH (PAAT ≤ 70 ms) and mild to moderate PH (PAAT = 109.9-70.01 ms) was 1.1% and 14% respectively. Multivariate analysis revealed that body mass index (β = -1.09, p < 0.0001), female gender (β = 6.25, p < 0.0001), age (β = -0.30, p = 0.02), African American race (β = -2.57, p = 0.007), physical activity (β = 0.005, p = 0.002), current smoking (β = -3.42, p = 0.001), left atrial dimension (β = -2.97, p = 0.009) and diastolic dysfunction (β = -13.06, p = 0.006) were statistically significant variables predicting PH. Conclusion:  In this large, observational study of young adults, pulmonary hypertension, as assessed by echocardiography, is common. Diastolic dysfunction, obesity, physical inactivity and smoking are associated with elevated pulmonary arterial pressure in young adults.
Maya Guglin; Swathy Kolli; Ren Chen
Related Documents :
22659364 - An anisotropic inelastic constitutive model to describe stress softening and permanent ...
6648394 - The björk-shiley tilting disc valve in the tricuspid position. 10-year experience.
2910604 - Prosthetic usage following major lower extremity amputation.
10333724 - Viability and enzymatic activity of cryopreserved porcine heart valve.
11564264 - Aneurysm of the distal posteroinferior cerebellar artery of extracranial origin: case r...
2850594 - Transcatheter arterial embolization for spontaneous rupture of hepatocellular carcinoma.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of clinical practice. Supplement     Volume:  -     ISSN:  1368-504X     ISO Abbreviation:  Int J Clin Pract Suppl     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-09-04     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9712380     Medline TA:  Int J Clin Pract Suppl     Country:  England    
Other Details:
Languages:  eng     Pagination:  13-9     Citation Subset:  IM    
Copyright Information:
© 2012 Blackwell Publishing Ltd.
Department of Cardiology, University of South Florida, Tampa, FL, USA Department of Medicine, University of South Florida, Tampa, FL, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Clinical implications of haemoptysis in patients with pulmonary arterial hypertension.
Next Document:  SNP Genotyping for the Genetic Monitoring of Laboratory Mice by Using a Microarray-based Method with...