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Determinants of pulmonary hypertension in young adults.
MedLine Citation:
PMID:  22943514     Owner:  NLM     Status:  In-Data-Review    
Background:  Risk factors of pulmonary hypertension (PH) are poorly understood. The objective of this study was to identify the determinants of PH in young adults. Methods:  We analysed a limited access dataset from the CARDIA (Coronary Artery Risk Development in Young Adults) study provided by the National Heart, Lung and Blood Institute. Pulmonary arterial pressure was assessed by the Doppler pulmonary artery acceleration time (PAAT). Socio-demographic characteristics, self-reported clinical variables, echocardiographic variables, pulmonary function tests, systemic blood pressure and body mass index calculated from height and weight were used in multivariate analysis. Results:  There were 4171 study subjects, mean age 24.9 ± 3.6 years, retained in year five with echocardiographic data available after five years of follow-up. The prevalence of severe PH (PAAT ≤ 70 ms) and mild to moderate PH (PAAT = 109.9-70.01 ms) was 1.1% and 14% respectively. Multivariate analysis revealed that body mass index (β = -1.09, p < 0.0001), female gender (β = 6.25, p < 0.0001), age (β = -0.30, p = 0.02), African American race (β = -2.57, p = 0.007), physical activity (β = 0.005, p = 0.002), current smoking (β = -3.42, p = 0.001), left atrial dimension (β = -2.97, p = 0.009) and diastolic dysfunction (β = -13.06, p = 0.006) were statistically significant variables predicting PH. Conclusion:  In this large, observational study of young adults, pulmonary hypertension, as assessed by echocardiography, is common. Diastolic dysfunction, obesity, physical inactivity and smoking are associated with elevated pulmonary arterial pressure in young adults.
Maya Guglin; Swathy Kolli; Ren Chen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of clinical practice. Supplement     Volume:  -     ISSN:  1368-504X     ISO Abbreviation:  Int J Clin Pract Suppl     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-09-04     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9712380     Medline TA:  Int J Clin Pract Suppl     Country:  England    
Other Details:
Languages:  eng     Pagination:  13-9     Citation Subset:  IM    
Copyright Information:
© 2012 Blackwell Publishing Ltd.
Department of Cardiology, University of South Florida, Tampa, FL, USA Department of Medicine, University of South Florida, Tampa, FL, USA.
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