Document Detail


Determinants of prolonged oral cecal transit time during late phase pregnancy.
MedLine Citation:
PMID:  8868312     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We examined the course of delayed oral cecal transit time (OCTT) and the impact of different variables in late pregnancy. Thirty-three women in late trimester were evaluated and 29 were re-tested post partum. Results were compared with 17 controls. A breath hydrogen test was used to measure OCTT. The impact of 3 demographic and 5 biochemical parameters was evaluated. Oral cecal transit time (99.2 +/- 7.8 min) during pregnancy was significantly prolonged compared both with controls (63.5 +/- 8.7 min) (p = 0.0042) and post partum (68.5 +/- 6.4 min) (p < 0.002). However, 40% during pregnancy had a normal OCTT. Post partum, 8 (29.6%) continued to have delayed OCTT. Serum free T4 levels were significantly lower than in controls (p < 0.0001) and post partum (p < 0.001), but did not correlate with OCTT. Gravidity rank correlated with OCTT (p = 0.022). By multivariate analysis, only 17% of the observed variability during pregnancy could be explained by these parameters. In controls, a formula including progesterone and gastrin levels was significant in explaining 54.7% of variability. Application of both formulae to post-partum returnees overpredicted OCTT; however, the one from pregnancy was more accurate. We conclude that in pregnancy multiple factors account for delayed OCTT and these may be different from controls and post partum. Pregnancy may still influence OCTT post partum.
Authors:
A Szilagyi; R Salomon; B E Smith; M Martin; E Seidman
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical and investigative medicine. Médecine clinique et experimentale     Volume:  19     ISSN:  0147-958X     ISO Abbreviation:  Clin Invest Med     Publication Date:  1996 Feb 
Date Detail:
Created Date:  1996-12-03     Completed Date:  1996-12-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7804071     Medline TA:  Clin Invest Med     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  20-7     Citation Subset:  IM    
Affiliation:
Department of Medicine, McGill University, Montreal, Quebec.
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MeSH Terms
Descriptor/Qualifier:
Adult
Breath Tests / methods
Cecum / metabolism*
Female
Gastrins / blood
Humans
Hydrogen / analysis
Lactulose / metabolism
Linear Models
Models, Statistical
Pregnancy
Pregnancy Trimester, First
Pregnancy Trimester, Second
Thyroxine / blood
Chemical
Reg. No./Substance:
0/Gastrins; 1333-74-0/Hydrogen; 4618-18-2/Lactulose; 7488-70-2/Thyroxine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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