| Determinants of p,p-dichlorodiphenyldichloroethane (DDE) concentration in adipose tissue in women from five European cities. | |
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MedLine Citation:
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PMID: 10433187 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To identify the determinants of p,p'-dichlorodiphenyldichloroethane (p,p'-DDE) in adipose tissue in subjects who participated in a cross-sectional study, we analyzed fatty acids, antioxidants, and p,p'-DDE in aspirates of adipose tissue of 328 postmenopausal women from 5 European countries. The overall mean of p,p'-DDE concentration was 1.66 microg/g of fatty acids (95% confidence interval = 1.46, 1.88). In a multiple-regression analysis, the main predictors of log10(p,p'DDE) were center of recruitment (p < .0001), adipose arachidic acid (p = .001), and adipose retinol (p = .04). These factors explained 14.9% of the overall variability of log10(p,p'-DDE). In our subjects, adipose tissue p,p'DDE concentrations were only weakly related with biomarkers reflecting intake of fish and other foods. This result is consistent with the notion that p,p'-DDE exists in different foods and, given the widespread contamination of the food chain, is relatively evenly distributed among foods. |
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Authors:
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M Inmaculada Sanz-Gallardo; E Guallar; P van Tveer; M P Longnecker; J J Strain; B C Martin; A F Kardinaal; J Fernández-Crehuet; M Thamm; L Kohlmeier; F J Kok; J M Martín-Moreno |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Archives of environmental health Volume: 54 ISSN: 0003-9896 ISO Abbreviation: Arch. Environ. Health Publication Date: 1999 Jul-Aug |
Date Detail:
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Created Date: 1999-08-12 Completed Date: 1999-08-12 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0212627 Medline TA: Arch Environ Health Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 277-83 Citation Subset: AIM; IM |
Affiliation:
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Department of Epidemiology and Biostatistics, National School of Public Health, Instituto de Salud Carlos III, Madrid, Spain. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adipose Tissue
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chemistry* Aged Antioxidants / analysis* Cross-Sectional Studies Dichlorodiphenyl Dichloroethylene / analysis* Diet / adverse effects Environmental Exposure / analysis* Environmental Monitoring / methods Europe Fatty Acids / analysis* Female Food Contamination Humans Insecticides / analysis* Linear Models Middle Aged Multivariate Analysis Postmenopause Questionnaires Risk Factors Urban Health* |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Fatty Acids; 0/Insecticides; 72-55-9/Dichlorodiphenyl Dichloroethylene |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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