Document Detail


Determinants of p,p-dichlorodiphenyldichloroethane (DDE) concentration in adipose tissue in women from five European cities.
MedLine Citation:
PMID:  10433187     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To identify the determinants of p,p'-dichlorodiphenyldichloroethane (p,p'-DDE) in adipose tissue in subjects who participated in a cross-sectional study, we analyzed fatty acids, antioxidants, and p,p'-DDE in aspirates of adipose tissue of 328 postmenopausal women from 5 European countries. The overall mean of p,p'-DDE concentration was 1.66 microg/g of fatty acids (95% confidence interval = 1.46, 1.88). In a multiple-regression analysis, the main predictors of log10(p,p'DDE) were center of recruitment (p < .0001), adipose arachidic acid (p = .001), and adipose retinol (p = .04). These factors explained 14.9% of the overall variability of log10(p,p'-DDE). In our subjects, adipose tissue p,p'DDE concentrations were only weakly related with biomarkers reflecting intake of fish and other foods. This result is consistent with the notion that p,p'-DDE exists in different foods and, given the widespread contamination of the food chain, is relatively evenly distributed among foods.
Authors:
M Inmaculada Sanz-Gallardo; E Guallar; P van Tveer; M P Longnecker; J J Strain; B C Martin; A F Kardinaal; J Fernández-Crehuet; M Thamm; L Kohlmeier; F J Kok; J M Martín-Moreno
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of environmental health     Volume:  54     ISSN:  0003-9896     ISO Abbreviation:  Arch. Environ. Health     Publication Date:    1999 Jul-Aug
Date Detail:
Created Date:  1999-08-12     Completed Date:  1999-08-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0212627     Medline TA:  Arch Environ Health     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  277-83     Citation Subset:  AIM; IM    
Affiliation:
Department of Epidemiology and Biostatistics, National School of Public Health, Instituto de Salud Carlos III, Madrid, Spain.
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MeSH Terms
Descriptor/Qualifier:
Adipose Tissue / chemistry*
Aged
Antioxidants / analysis*
Cross-Sectional Studies
Dichlorodiphenyl Dichloroethylene / analysis*
Diet / adverse effects
Environmental Exposure / analysis*
Environmental Monitoring / methods
Europe
Fatty Acids / analysis*
Female
Food Contamination
Humans
Insecticides / analysis*
Linear Models
Middle Aged
Multivariate Analysis
Postmenopause
Questionnaires
Risk Factors
Urban Health*
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Fatty Acids; 0/Insecticides; 72-55-9/Dichlorodiphenyl Dichloroethylene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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