| Determinants of postexercise heart rate recovery in patients with the obstructive sleep apnea syndrome. | |
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MedLine Citation:
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PMID: 19837829 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Young patients with obstructive sleep apnea syndrome (OSAS) display an attenuated heart rate recovery (HRR) during the first minute (HRR-1) and the first 2 min (HRR-2) postexercise. We sought to compare determinants of HRR-1 and HRR-2 in OSAS and to assess whether these associations depend on age. METHODS: Exercise testing with measurements of HRR-1 and HRR-2 was performed in 54 patients with untreated OSAS (median [interquartile range] apnea-hypopnea index 27.5 [12.0-42.4] h(-1), desaturation index [DSI] 10.6 [5.1-25.0] h(-1)). RESULTS: Overall, higher DSI (P < .001) and higher total cholesterol ([TC] P = .02) were independent predictors of lower HRR-1, whereas lower peak heart rate (P < .001), higher resting heart rate (P = .006), and higher DSI (P = .01) were independently associated with lower HRR-2. In the below-median age group (age <or= 48 years; n = 27), higher DSI (P = .002) was the only independent predictor of lower HRR-1, and lower peak heart rate (P < .001) and higher DSI (P = .003) were independently associated with lower HRR-2. In contrast, in the above-median age group (age > 48 years; n = 27) higher TC (P = .006), higher insulin resistance (P = .009), and higher resting heart rate (P = .048) were independently associated with lower HRR-1, and lower estimated glomerular filtration rate (P = .001), higher resting heart rate (P = .002), higher TC (P = .005), and lower peak heart rate (P = .01) were independently associated with HRR-2. CONCLUSIONS: Assessment of HRR-2 provides additional information on different aspects of OSAS compared with HRR-1. Markers of OSAS severity, such as DSI, are independently associated with HRR in younger patients only, whereas in older patients, HRR reflects OSAS-related metabolic and renal dysfunction. |
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Authors:
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Micha T Maeder; Peter Ammann; Otto D Schoch; Hans Rickli; Wolfgang Korte; Christoph H?rny; Jonathan Myers; Thomas M?nzer |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2009-10-16 |
Journal Detail:
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Title: Chest Volume: 137 ISSN: 1931-3543 ISO Abbreviation: Chest Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-02-05 Completed Date: 2010-03-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0231335 Medline TA: Chest Country: United States |
Other Details:
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Languages: eng Pagination: 310-7 Citation Subset: AIM; IM |
Affiliation:
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Baker IDI Heart and Diabetes Institute, Melbourne, Australia. micha.maeder@bluewin.ch |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Body Composition Electrocardiography Exercise Test / methods* Female Follow-Up Studies Heart Rate / physiology* Humans Male Middle Aged Polysomnography Prognosis Prospective Studies Recovery of Function / physiology* Sleep Apnea, Obstructive / diagnosis, physiopathology* Spirometry Ventricular Function / physiology* Young Adult |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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