| Determinants of plasma homocyst(e)ine in patients with nephrotic syndrome. | |
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MedLine Citation:
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PMID: 10868477 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hyperhomocyst(e)inemia is an independent risk factor for atherothrombosis in several clinical settings in which renal function is impaired, but its prevalence in the nephrotic syndrome has not been investigated in detail, even though this syndrome provides an excellent model in which to study a possible link between albuminuria, proteinuria, and hyperhomocyst(e)inemia. We obtained plasma and urine from 27 patients with biopsy-confirmed membranous glomerulonephritis presenting nephrotic syndrome and 27 matched controls and determined the concentrations of homocyst(e)ine and proteins considered putative markers of glomerular and tubular function. Hyperhomocyst(e)inemia, defined as the mean +SD of the plasma homocyst(e)ine concentration of the controls [plasma homocyst(e)ine concentration >10.8 micromol/l] was present in 26% of the patients with nephrotic syndrome but in only 7.4% of the controls. Furthermore, the degree of hyperhomocyst(e)inemia was more severe in the nephrotic patients than in the controls. The existence of renal failure, tubular damage, and, interestingly, relatively well conserved glomerular function barrier were the main predictors of increased levels of plasma homocyst(e)ine. In conclusion, hyperhomocyst(e)inemia is a frequent cardiovascular risk factor present in patients with nephrotic syndrome and renal failure, but it is not directly associated with proteinuria. |
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Authors:
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J Joven; R Arcelús; J Camps; J Ordóñez-Llanos; E Vilella; F González-Sastre; F Blanco-Vaca |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of molecular medicine (Berlin, Germany) Volume: 78 ISSN: 0946-2716 ISO Abbreviation: J. Mol. Med. Publication Date: 2000 |
Date Detail:
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Created Date: 2000-10-24 Completed Date: 2000-10-24 Revised Date: 2011-07-08 |
Medline Journal Info:
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Nlm Unique ID: 9504370 Medline TA: J Mol Med (Berl) Country: GERMANY |
Other Details:
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Languages: eng Pagination: 147-54 Citation Subset: IM |
Affiliation:
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Centre de Recerca Biomèdica, Unidad de Investigación Clínico-Experimental, Hospital Universitari de Sant Joan, Facultad de Medicina de Reus, Spain. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Albuminuria / blood Case-Control Studies Creatine / metabolism Diabetes Mellitus / blood, urine Female Homocysteine / blood*, urine Humans Male Middle Aged Multivariate Analysis Nephrotic Syndrome / blood*, urine Proteinuria / blood Risk Factors |
| Chemical | |
Reg. No./Substance:
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454-28-4/Homocysteine; 57-00-1/Creatine |
| Comments/Corrections | |
Comment In:
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J Mol Med (Berl). 2000;78(3):119-20
[PMID:
10868473
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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