Document Detail

Determinants of peritoneal dialysis technique failure in incident US patients.
MedLine Citation:
PMID:  23032086     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Switching from peritoneal dialysis (PD) to hemodialysis (HD) is undesirable, because of complications from temporary vascular access, disruption of daily routine, and higher costs. Little is known about the role that social factors play in technique failure.
DESIGN, SETTING, PARTICIPANTS, MEASUREMENTS: We followed for 3 years a nationally representative cohort of US patients who initiated PD in 1996 - 1997. Technique failure was defined as any switch from PD to HD for 30 days or more. We used Cox regression to examine associations between technique failure and demographic, medical, social, and pre-dialysis factors. We estimated hazard ratios (HRs) with 95% confidence intervals (CIs).
RESULTS: We identified an inception cohort of 1587 patients undergoing PD. In multivariate analysis, female sex (HR: 0.78; 95% CI: 0.64 to 0.95) was associated with lower rates of technique failure, and black race [compared with white race (HR: 1.48; 95% CI: 1.20 to 1.82)] and receiving Medicaid (HR: 1.48; 95% CI: 1.17 to 1.86) were associated with higher rates. Compared with patients who worked full-time, those who were retired (HR: 1.49; 95% CI: 1.07 to 2.08) or disabled (HR: 1.38; 95% CI: 1.01 to 1.88) had higher rates of failure. Patients with a systolic blood pressure of 140 - 160 mmHg had a higher rate of failure than did those with a pressure of 120 - 140 mmHg (HR: 1.24; 95% CI: 1.00 to 1.52). Earlier referral to a nephrologist (>3 months before dialysis initiation) and the primary decision-maker for the dialysis modality (physician vs patient vs shared) were not associated with technique failure.
CONCLUSIONS: This study confirms that several socio-demographic factors are associated with technique failure, emphasizing the potential importance of social and financial support in maintaining PD.
Jenny I Shen; Aya A Mitani; Anjali B Saxena; Benjamin A Goldstein; Wolfgang C Winkelmayer
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Publication Detail:
Type:  Journal Article     Date:  2012-10-02
Journal Detail:
Title:  Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis     Volume:  33     ISSN:  1718-4304     ISO Abbreviation:  Perit Dial Int     Publication Date:    2013 Mar-Apr
Date Detail:
Created Date:  2013-03-12     Completed Date:  2013-09-26     Revised Date:  2014-11-13    
Medline Journal Info:
Nlm Unique ID:  8904033     Medline TA:  Perit Dial Int     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  155-66     Citation Subset:  IM    
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MeSH Terms
Cohort Studies
Kidney Failure, Chronic / complications,  epidemiology*,  therapy*
Middle Aged
Peritoneal Dialysis* / adverse effects,  methods
Referral and Consultation
Risk Factors
Socioeconomic Factors
Treatment Failure
United States
Comment In:
Perit Dial Int. 2013 Mar-Apr;33(2):112-5   [PMID:  23478371 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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