| Determinants of peak V(O2) in peripheral arterial occlusive disease patients. | |
| | |
MedLine Citation:
|
PMID: 10843347 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Peripheral arterial occlusive disease (PAOD) patients with intermittent claudication are functionally limited and deconditioned. This study examined whether peak aerobic capacity (V(O2) peak) was associated with PAOD severity, muscle mass, and comorbidities in 109 PAOD patients (93 men and 16 women) aged 48-86 years. The V(O2) peak (1.12+/-0.34 L/min), percentage body fat (30.6+/-8.3%), lean tissue mass of the total body (51.4+/-8.4 kg), lean tissue mass of the legs (16.6+/-3.0 kg), and appendicular skeletal mass (22.8+/-4.2 kg) were determined. The lean tissue mass of the total body (r = .44), lean tissue of the legs (r = .43) and resting ankle/brachial systolic pressure index (ABI; r = .41) correlated with peak V(O2) (all p < .001). None of the comorbidity variables (obesity, arthritis, coronary artery disease, hypertension, diabetes, and smoking history) were significantly associated with peak V(O2) except smoking status. The final model for the prediction of peak V(O2) included lean tissue mass of the legs, resting ABI, smoking status, and ABI x smoking status (r2 = .37,p < .001). In older patients with intermittent claudication, lean tissue mass is an important determinant of physical performance independent of PAOD severity and smoking status. Prevention of muscle atrophy may preserve ambulatory function and peak exercise capacity in older PAOD patients. |
| | |
Authors:
|
A S Ryan; L I Katzel; A W Gardner |
Related Documents
:
|
19563567 - Effect of isometric exercise and body scanning on cigarette cravings and withdrawal sym... 9717887 - Prediction of peak oxygen consumption in patients with intermittent claudication. 15507887 - Reproducibility of proximal and distal transcutaneous oxygen pressure measurements duri... 10603337 - Intermittent locomotion increases endurance in a gecko. 8450597 - Effects of rhuepo therapy on exercise capacity in hemodialysis patients with coronary a... 2708237 - Corticosteroids decrease airway hyperresponsiveness in the basenji-greyhound dog model ... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: The journals of gerontology. Series A, Biological sciences and medical sciences Volume: 55 ISSN: 1079-5006 ISO Abbreviation: J. Gerontol. A Biol. Sci. Med. Sci. Publication Date: 2000 Jun |
Date Detail:
|
Created Date: 2000-06-27 Completed Date: 2000-06-27 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 9502837 Medline TA: J Gerontol A Biol Sci Med Sci Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: B302-6 Citation Subset: AIM; IM |
Affiliation:
|
Department of Medicine, University of Maryland School of Medicine, and the Geriatric Research, Education and Clinical Center, Baltimore, USA. alice@grecc.umaryland.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Aged, 80 and over Arterial Occlusive Diseases / metabolism* Body Mass Index Female Humans Male Middle Aged Oxygen / metabolism* Peripheral Vascular Diseases / metabolism* Severity of Illness Index |
| Grant Support | |
ID/Acronym/Agency:
|
KO1-A600747//PHS HHS; KO1-AG-00657/AG/NIA NIH HHS; P60-AG12583/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
|
7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Extended longevity in Drosophila is consistently associated with a decrease in developmental viabili...
Next Document: Age effects on the adaptive response of the female rat heart following aortic constriction.