| Determinants of pathogenicity in Xanthomonas campestris pv. vesicatoria are related to proteins involved in secretion in bacterial pathogens of animals. | |
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MedLine Citation:
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PMID: 1472717 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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One of the model systems investigated for studying plant bacterial pathogenesis is Xanthomonas campestris pv vesicatoria, the causal agent of bacterial spot disease of pepper and tomato. Genes necessary for both basic pathogenicity and the induction of the hypersensitive response in resistant plants (hrp genes) were previously isolated from X. c. pv. vesicatoria and characterized genetically. As a first step toward functional analysis, part of the hrp gene cluster, making up several loci, was sequenced. Here, we report the first indications of the function of hrp genes. Striking similarities to proteins from the mammalian pathogens Shigella flexneri, Yersinia enterocolitica, Y. pestis, and other bacteria were discovered. Proteins encoded by genes within the X. c. pv. vesicatoria loci hrpA, hrpB, and hrpC are similar to ATPases and to Yersinia Ysc and LcrD proteins, which are involved in secretion of Yop proteins, a particular class of essential pathogenicity factors produced by Yersinia species. This finding indicates, for the first time, that the fundamental determinants of pathogenicity may be conserved among bacterial pathogens of plants and animals. We hypothesize that hrp genes are involved in the secretion of molecules essential for the interaction of X. c. pv. vesicatoria with the plant. |
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Authors:
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S Fenselau; I Balbo; U Bonas |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Molecular plant-microbe interactions : MPMI Volume: 5 ISSN: 0894-0282 ISO Abbreviation: Mol. Plant Microbe Interact. Publication Date: 1992 Sep-Oct |
Date Detail:
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Created Date: 1993-02-01 Completed Date: 1993-02-01 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9107902 Medline TA: Mol Plant Microbe Interact Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 390-6 Citation Subset: IM |
Affiliation:
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Institut für Genbiologische Forschung Berlin GmbH, Germany. |
| Data Bank Information | |
Bank Name/Acc. No.:
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GENBANK/M83225; M91664; X63698; SWISSPROT/P80151; P80152; P80153 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Animals Bacterial Proteins / genetics* DNA, Bacterial / genetics Genes, Bacterial Molecular Sequence Data Plants / microbiology Sequence Homology, Amino Acid Species Specificity Virulence / genetics Xanthomonas / genetics*, pathogenicity* Yersinia / genetics |
| Chemical | |
Reg. No./Substance:
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0/Bacterial Proteins; 0/DNA, Bacterial |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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